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Project ID: ICA3-CT-2002-10033
Financiado con arreglo a: FP5-INCO 2
País: Italy

Production of Triacetylhydroxytyrosol from olive mill waste waters for use as stabilized bioantioxidant

Triacetyhydroxytyrosol was very efficiently produced as a highly pure stabilized antioxidant compound by a short treatment of olive mill waste water (OMWW) organic extracts, rich in hydroxytyrosol, with an acetylating mixture composed of HClO4-SiO2 and Ac2O (Chakborti and Gulhane reaction), in mild and safe conditions. A successive single step of middle pressure liquid chromatography
(MPLC) purification of the reaction product was performed, with an overall yield of 35.6%.

The purified natural triacetylhydroxytyrosol confirmed the same strong protective effects against the oxidative stress in human cells as the corresponding synthetic compound, likely because of the biochemical activation of the acetyl derivative into the active parent hydroxytyrosol by esterases.

The synthetic triacetylhydroxytyrosol was prepared by reaction of synthetic hydroxytyrosol in presence of pyridine and acetic anhydride. Hydroxytyrosol was in turn prepared by reduction of 3,4-hydroxyphenilacetic acid.

Reported by

University of Naples Federico II
-Dipartimento di Scienze del Suolo, della Pianta , dellęAmbiente e della Produzione Animale (DiSSPAPA)
80055 Portici
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