Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

Novel Acute Myelogenous Leukemia (ALM) treatment paradigm

HDAC inhibitors (HDACi's) induce expression of the death ligand TRAIL and this molecular event is responsible for apoptosis in acute myeloid leukaemia systems after epigenetic treatment.

This has been the first time in which TRAIL is specifically linked to HDACi's and explains the previously noted tumour-selective action of some HDACi's.

- showed that TRAIL-induction causes HDACi-induced apoptosis,
- described the corresponding mechanisms,
- separated the effects of HDACi action on inhibition of cell cycle progression, differentiation and apoptosis, and
- demonstrated TRAIL induction in AML patient's blasts.

Reported by

Dipartamento di Patologia Generale
Via L. Crecchio, 7, I-80138, Napoli, Italia
80138 Napoli
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