Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

Effects of RA on micro-environmental stimuli promoting growth and survival of B cells

Proliferation of MCL cells is not significantly enhanced by physiologic concentrations of dexamethasone or hydrocortisone. Moreover, these steroid hormones are unable to antagonize the antiproliferative effects exerted by RA in MCL cells.

These results seem to rule out that endogenous GC could promote the growth of MCL cells, as instead observed for EBV-immortalized B lymphocytes. Moreover, 9-cis-RA sensitizes MCL cells to TRAIL-dependent apoptosis by a mechanism not involving TRAIL receptors. RA isomers, and particularly 9-cis-RA, are able to inhibit the growth promoting effect induced in primary MCL cells by CD40 activation alone or in combination with IL-4.

Immunohistochemical analysis showed that significant numbers of CD40L-expressing lymphoid cells are present in lymph node biopsies of MCL patients. These results, therefore, further strengthen the possibility that triggering of CD40 by infiltrating CD40L+ cells may continuously promote the growth of MCL cells in vivo.

On these grounds, our findings that RA inhibits basal MCL proliferation as well as MCL growth-promoting effects exerted by microenvironmental factors make these compounds highly attractive in terms of potential clinical efficacy in this setting.

Información relacionada

Reported by

Cancer Bio-Immunotherapy Unit
Via F. Gallini 2
33081 Aviano
See on map
Síganos en: RSS Facebook Twitter YouTube Gestionado por la Oficina de Publicaciones de la UE Arriba