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Highly sensitive optical transducer based on interferometry

UTU has successfully built up an Integrated Optical Mach-Zehnder setup, which has been tested with well-investigated antibody reactions. It is possible to produce a multi-analyte interferometric sensor and to evaluate those results with the help of Artificial Neural Networks.

Due to the lack of MIPs delivering specific binding signals in water, SPR (Surface Plasmon Resonance) and RIfS (Reflectometric Interference Spectroscopy) were used as alternative optical method to test the MIPs supplied by TUM and LUND in organic solvents. Specific, time-resolved and reproducible binding signals were detected with the MIPs imprinted against atrazine.

Within the data evaluation part a chemometric model could be developed which is in principle able to predict endocrine disrupting potential from multi-analyte sensor signals, but could not be tested with MIPs, again because of the lack of MIPs which could be measured in water with the Mach-Zehnder.

Reported by

University of Tübingen, Institute for Physical and Theoretical Chemistry
Auf der Morgenstelle 8
72076 Tübingen
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