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Procedure for preparation of molecularly imprinted polymer films based on self-assembly of MIP nanoparticles

Thin molecularly imprinted polymer (MIP) films based on self-assembly of nanoparticles

MIP nanoparticles were coated on a gold-coated glass substrate for use in SPR and other evanescent-wave-based transducers. The gold surface is first modified with a self-assembled monolayer (SAM) of 11-mercaptoundecanoic acid (MUA). This layer is then overlayed with a thin layer of polyethylene imine (PEI) or polyallylamine forming ion pairs with the MUA.

MIP nanoparticles based on methacrylic acid as the functional monomer can be directly adsorbed onto this film in form of a monolayer, via ionic interactions. If the functional monomer contains a basic function, a polysulfonic acid underlayer is required. The coating procedure was followed in an SPR assembly.

These MIP films can be used as the selective recognition layers in biosensors.

Reported by

ARC Seibersdorf research GmbH
Forschungszentrum Seibersdorf
2444 Seibersdorf
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