Community Research and Development Information Service - CORDIS

Utility of holoTC

The project found that holoTC is superior to plasma vitamin B12 in identifying individuals with vitamin B12 deficiency and disclosed the usefulness of the holoTC assay to investigate the uptake of vitamin B12. The latter will be further explored in order to devise a routine method for the use of holoTC to evaluate a patient's capacity to absorb vitamin B12.

The project further found that usually analysis of total TC and TC saturation would not add information compared to analysing holoTC alone. However, measurement of total TC may be useful to identify individuals lacking the protein and to explore unusual holoTC results.

The project identified a method whereby total TC can be measured employing the holoTC assay. Work to clarify the future of total TC will be continued.

Related information

Reported by

Aarhus University Hospital
Norrebrogade 44
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