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Systemic DNA vaccination induces elevated immune responses in blood before and after challenge

Antibody responses were elevated prior to challenge in animals immunised systemically with gag, gagenv, or gagenvIFN. In contrast, T cell proliferative responses were elevated after systemic immunisation with gag, env, or gag+env before challenge. Cytotoxic T cell responses were only observed in animals immunized with gag+env, while IFNg production was not elevated in any group. After challenge, elevated antibody responses were found when gagenv and gagenvIFN immunized animals were compared to controls. All immunised animals showed elevated T cell proliferative responses following challenge, while cytotoxic responses were elevated only in env and gagenv immunized groups. IFNg production by T cells was elevated after gag or env immunization, but not gag+env immunization. The results show that systemic MVV DNA immunisation primes for T cell responses but is less efficient at priming humoral responses.

The end users of the information are other scientists working in the field of SRLV control, or working with other lentiviruses, or working with other plasmid DNA vaccines, or in the general area of vaccines and immune responses, or in the general area of lentivirology.

Commercial companies may be interested in the information that T cell proliferation to MVV EV1 antigens was not associated with IFNg production, but without the identity of the cytokine(s) produced by the proliferating T cells being known it is unlikely that anything of commercial value can be pursued. Further work is required to determine the identity of the cytokines produced by the primed T cells.

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