Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

Sample characteristics EPOS target group

Multi-dimensional, i.e. clinical, sociodemographic, biographical, personality, functional, neurocognitive and biological characteristics of a sample of 246 probands putatively at risk for psychosis included into EPOS at 6 centres in 4 European regions (EPOS Group 2006).

First results of ongoing data analyses comprise e.g. attenuated positive and basic symptoms being main at-risk inclusion criteria, very high rates of current co-morbid psychiatric disorders and functional impairment at intake, self-reported high levels of non-physical disabilities and low levels of quality of life both comparable to schizophrenia patients, relatively diverse numbers and kinds of contacts with mental health professionals before attending specialized care in different regional health care systems and increased prefrontal gyrification index (a measure of cortical folding) comparable to schizophrenia patients.

These first results support the hypothesis that persons putatively at risk for psychosis are already in need for specialised mental health care, independently from whether or not they will actually develop a frank psychosis, and seem to indicate a biological correlate of the at risk mental state. Potential end-users are governmental and non-governmental agencies and organizations, clinicians and researchers in the areas of mental health care and policy.

As the main benefit, the acquired knowledge will help to implement and sustain early detection and prevention programmes adapted to European mental health care systems and the needs of the help-seeking individuals.

Reported by

University Hospital of Cologne
Kerpener Str. 62
50924 Cologne
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