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Anti-oxidative effect

The antioxidative effect of wood extractives was first established by the evaluation of the capacity of extractive compounds for inhibition of lipid peroxidation (PEROX-test) and peroxyl radical scavenging (TRAP-test) in vitro. In both tests, the detection of free radicals is based on sensitive cheluminescent techniques. Validity of the assays has been tested by various structurally in related antioxidant and peroxyl radical scavenging molecules.

An evaluation of the inhibition of lipid peroxidation has been carried out on the first ethanol crude extracts.32 samples of wood extractives have been tested and the different test samples showed the antioxidative effect, even though at different levels based on the nature of the samples.During a first series of test, Pinus pinaster knotwood and Pinus nigra knotwood were demonstrated as the most potent samples. However, in a second series of tests, Larix decidua and Abies alba knotwood both showed strong lipid peroxidation preventing and peroxyl radical scavenging potentialSix properties of the extracts were determined (which will be detailed in other results' description):- inhibition of lipid peroxidation- scavenging of peroxyl radicals- Inhibition of oxidation of low density lipoprotein (LDL) lipids- Inhibition of myeloperoxidase activity- inhibition of oxidative burst- effects on DNA oxidabilityBiological effects of wood extractives were studied by a carefully selected repertoire of biotests.

In some cases the potency of wood extractives even exceeded that of the reference compounds. Biological activity was found in samples from most wood species, different parts of trees (knots, sapwood, bark) and in their water and ethanol extracts. In particular, various extracts of Larix decidua, Abies alba and Pinus nigra showed strong potential in several test systems.

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