Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

Cellular defence function - Immunomodulatory activity

The aim of these tests was to study how extractive compounds affect the ability of neutrophils and other cells of the host s defence to produce reactive oxygen species in vitro.

Extractives have been tested for their ability to depress overactivity of the cellular defence functions. It is today well known that the microbicidical action of human neutrophils is due to the production of reactive oxygen species, hypochlorus acid and tyrosyl radical.

Reactive species produced by the oxidative burst and myeloperoxidase activity are the ultimate damaging agents. It seems therefore logical that a direct way for attenuation of the damage due to overactivity would be effective inhibition of oxidative burst and myeloperoxydase activity.

Three potent extracts inhibit ROS under the specified experimental conditions:
- Populus deltoides knots and bark extracts,

Altogether 36 samples of wood extracts were tested. The effects of wood extractives were compared to appropriate reference compounds, hydroxymatairesinol and nitecapone (a synthetic drug with strong myeloperoxidase inhibiting activity). Strongest of the wood extractives showed potency that was comparable to that of nitecapone and stronger than effect of hydroxymatairesinol.

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