Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

Anti-tumoric properties

Anti-tumorigenic properties have been screened with the in vitro test of compounds to regulate spontaneous apoptosis and proliferation in tumour cell battery and to modulate the sensitivity on physiologically induced apoptosis. Cell proliferation has been determined as cell population growth in the presence of varying concentrations of the test compound. The compounds that directly induce cell death and inhibit cancer cell proliferation would be useful for cancer therapeutics.

Based on previous testing, three samples of wood extracts with strong antioxidant potential were selected for testing of the effects on DNA oxidability. Effects on oxidation of DNA were studied by ability of wood extractives either to cause oxidation or prevent UV-induced oxidation of calf thymus DNA in vitro. The dose and spectrum of UV-light was comparable to what European populations are exposed during a normal sunny summer day. DNA was isolated by conventional extraction procedures, and DNA oxidation measured by the relative amount of 8-oxo-deoxyguanosine.

This test is regarded as an indication of the ability of test substances either to cause or prevent oxidation of DNA. Since the test is qualitative or, at best, only semi-quantitative in nature, comparison to potency of reference compounds is not scientifically justified. None of the studied samples caused DNA oxidation, and all of them showed distinct ability to prevent UV-induced DNA damage in vitro: Dead knotwood of Abies alba, living knotwood of Larix decidua and Pinus nigra knotwood.

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