Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

Gene Ontology Annotation (GOA) Database

The GOA project provides high-quality Gene Ontology (GO) annotations to proteins in the UniProt Knowledgebase (UniProtKB).

Since joining the GO Consortium (GOC) in 2001, GOA has been primarily responsible for the integration and release of GO annotation to the human proteome. Starting in 2006, as part of a new GOC reference genome-working group, GOA is committed to the comprehensive annotation of a set of disease-related gene products in human, mouse and rat species. It is hoped that by generating a reliable set of GO annotations to these genomes, the GOC will empower comparative methods used in first pass annotation of other proteomes.

Because of the multi-species nature of the UniProtKB, GOA also assists in the curation of another 100,000 species. This involves electronic annotation and the integration of high-quality GO annotation from many model organism and specialist groups. This effort ensures that the GOA datasets remain a key reference and a comprehensive source of annotations for UniProtKB.

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