Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

Chimeric and deleted C strain mutant viruses

Vaccine candidates Flc9 (BVDVII E2 exchanged in C-strain), Flc11 (BVDVII Erns exchanged in C-strain) and vaccine strains C-strain (Flc2) and a trans-complemented Erns deletion mutant (Flc23) derived from the C-strain were studied in animal experiments. PBMCs of these vaccinated animals were used in CTL assays. It was concluded that the Erns, E2 and NS3-4B* proteins were targets for the cellular immune system. The observed cellular immune response was short in time and differences between the vaccine strains were relatively small.

Reported by

WAGENINGEN UNIVERSITY RESEARCH
P.O. BOX 65 8200 AB, LELYSTAD
8200 AB LELYSTAD
Netherlands
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