Community Research and Development Information Service - CORDIS

Biodegradable and resorbable polymeric coatings for drug delivery

Drug targeting using polymeric microspheres injected into the blood circulation could have considerable impact in many disease conditions, especially cancer chemotherapy. The project aims to develop novel biodegradable polymeric coating agents based upon polyesters, polyamines and polyethers that will be absorbed or grafted to drug loaded microspheres. The chosen polymer will cause particles injected into the blood to remain in the circulation (and thus to avoid deposition at undesired sites such as the resident macrophages in liver) or to be targeted passively to the bone marrow. Coated particles carrying attached homing moieties in the form of sugar residues or monoclonal antibodies will be developed for active targeting opportunities.

Biodegradable and bioresorbable polymers suitable for the coating of preformed carrier particles have been synthesised. They include polylactide, polycoglycolide, polymalic acid derivatives, poly L-lysine citramide and modified polyamidoamines.
Emulsification techniques have been used for the preparation of polylactide, polycoglycolide and albumin microspheres of sizes of 100nm and 1000nm.
Biodegradation studies on related particle samples have commenced, and chemical procedures for the coupling of polyoxyethylene groups onto linear serum albumin have been developed.
Diagnostic secondary ion mass spectroscopy (SIMS) spectra of coating polymers and particles have been obtained as background to the surface analysis of coated systems.

Reported by

UNIVERSITY OF NOTTINGHAM
University Park
NG7 2RD NOTTINGHAM
United Kingdom
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