Community Research and Development Information Service - CORDIS

Key components of brain-pituitary gonad-axis identified and characterized on molecular level in salmon, sea bass and trout

A range of new hormone receptor variants were discovered and characterized, such as gonadotropin releasing hormone receptors (GnRH-R's) and estrogen receptors (ER's) in trout and sea bass, as well as follicle stimulating hormone receptor (FSHR), luteinising hormone receptor (LHR) and two androgen receptor forms (AR a and AR b) in Atlantic salmon. The localization of these receptors in tissues and cell types has been thoroughly investigated with real time quantitative PCR and in situ hybridization, along with pharmacological characterization to study how various ligands bind and activate these receptors.

The mRNA expression profiles measure be-real time qPCR of these genes have been put into the context of pubertal and/or seasonal development, as well as photoperiod treatments, in both male and female sea bass, rainbow trout and Atlantic salmon, by correlating the expression profiles with the stage of gonadal development (stage of spermatogenesis or oogenesis) and plasma sex steroid profiles.

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