Final Report Summary - CARDIOWORKBENCH (Drug Design for Cardiovascular Diseases: Integration of in Silico and in Vitro Analysis) The CARDIOWORKBENCH project was based on target screening and validation of molecular targets and addresses cardiovascular diseases (CADs), which are multifactorial and are characterised by complex synergies between genetic and environmental factors which makes target screening and validation extremely difficult. The main aim of the project was to optimise drug design for CADs. Specifically at the outset of the project, expected end project results were the identification of new molecular targets involved in atherosclerosis and related CADs, the improvement of target screening and validation and the selection, synthesis and test of new drug candidates for treatment. Other objectives were the development of mathematical models for the prediction of the effects of drugs on the behaviour of cardiovascular cells. On the basis of a patient panel the project has originated in an integrative bioinformatics database system. The application of computational tools has singled out new target, and chemical entities related to this target have therefore been considered. In addition, further results achieved at the very end of the project have highlighted some new potential targets. It is intended to focus on these potential targets when setting up a new research project. This future project will involve some of the partners of CARDIOWORKBENCH. Related documents Final Report - CARDIOWORKBENCH (Drug Design for Cardiovascular Diseases: Integration of in Silico and in Vitro Analysis)
