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NEMAGENETAG Informe resumido

Project ID: 503334
Financiado con arreglo a: FP6-LIFESCIHEALTH
País: Greece

Final Report Summary - NEMAGENETAG (Nematode Gene-Tagging Tools and Resources)

The project aimed to develop cutting-edge tools and resources that will facilitate modelling of human pathologies in Caenorhabditis elegans, and advance our understanding of animal development and physiology. The nematode C. elegans is a widely appreciated, powerful platform in which to study important biological mechanisms related to human health. More than 65 % of human disease genes have homologues in the C. elegans genome, and essential aspects of mammalian cell biology, neurobiology and development are faithfully recapitulated in this organism.

Partners aimed to develop cutting-edge tools and resources that will facilitate modelling of human pathologies in C. elegans, and advance understanding of animal development and physiology. Specifically, they optimised and automated existing transposon-mediated mutagenesis methodologies based on the Mos1 transposable element, in addition to developing alternatives using the Minos transposon system. Partners exploited these tools to generate and evaluate a collection of transposon-tagged mutants, aiming to cover the complete genome of approximately 20 000 genes.

Further, they established the infrastructure necessary for managing and maintaining this resource. To achieve these goals, they assembled a group of experts with pioneering contributions to transposon and genomics technologies in C. elegans, who were also exceptionally proficient in the biology of the nematode.

Their participant, MAIA Scientific, a company specialising on platform technology development, provided solutions essential for the automation and streamlining of the processes involved in generating libraries of mutant strains. The final product of the focused project - a comprehensive collection of transposon-tagged alleles - together with the acquisition of efficient transposon-based tools for mutagenesis and transgenesis in C. elegans, should be of great value to the European and international scientific community.

Project efforts strengthened European research in the strategic area of functional genomics and yielded a wealth of information on gene function, immediately relevant to pharmaceutical research and development (R&D).

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