Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

Final Activity Report Summary - DIAPEP (Diagnostic peptide pattern for early stage disease detection)

The Marie Curie transfer of knowledge (Tok) project DIAPEP was related to the development and clinical acceptance of mass spectrometric peptide patterns (MSPPs) for diagnostic use.

This novel multimarker diagnostic tool was, by the time of the project completion, still at an early stage of development in laboratories and industry. The aim of the project was to develop stable, diagnostically meaningful MSPPs in order to evaluate the approach and, if possible, to convert this tool into a clinically applicable, accepted and approved diagnostic procedure in screening, staging, or treatment follow-up.

Philips Research recognised the importance and the potential of molecular imaging and molecular diagnostics in the future of health care. However, diagnostic areas outside of diagnostic imaging, e.g. in vitro diagnostic (IVD), genomics, proteomics, the required biomedical and clinical chemical knowledge as well as the developments of a molecular diagnostics platform required researchers with different background and practical medical experience. The Marie Curie program DIAPEP provided access to such biomedical and biochemical knowledge.

Two Marie Curie ToK fellows with experience in proteomics and mass spectrometry worked at Philips Research for 18 months each in close collaboration with local clinical partners. The fellows taught full day courses on MS technology several times to Philips researchers as well as to our clinical partners. They implemented and robotised rigorous quality control procedures to arrive at mass spectrometry results that were sufficiently accurate to be of clinical relevance. Our fellows became an essential, integrated and important part of our clinical programme aiming to:

1. discover novel diagnostic patterns suitable to distinguish prostate cancer patients from healthy persons and:
2. to monitor host response in sepsis using a mouse animal model.

The entire topic was novel to Philips Research at project start-up and the input by the two fellows was essential to develop protocols for tissue, serum and urine samples, to establish quality control measures and to properly analyse corresponding results. Four invention disclosures, several poster presentations and conference contributions resulted from the activities of the fellows. Based on this Marie-Curie project Philips Research developed to a much better position to assess the value of SELDI-ToF-mass spectrometry and MSPP with respect to its usefulness in diagnostics and was furthermore able to compare this approach with alternative mass spectrometry technologies. One of the fellows was offered a position at Philips Research after her Marie Curie fellowship in order to continue corresponding scientific investigations, thus indicating the level of impact and appreciation the program had.

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