Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS

Final Activity and Management Report Summary - HS GENOMICS (High resolution mapping of genetic loci underlying variation in gene expression using a heterogeneous stock of mice)

A proportion of the genetic variants underlying complex traits do so through their effects on gene expression, so an important challenge is to discover the genetic basis for gene transcription. So far, the potential of mapping both quantitative trait loci (QTLs) and expression quantitative trait loci (eQTLs) in rodents has been limited by the low mapping resolution inherent in crosses between inbred strains.

We provide a megabase resolution map of thousands of eQTLs in hippocampus, lung, and liver samples from genetically heterogeneous mice (a so called heterogenous stock, HS) in which 843 QTLs have also been mapped at megabase resolution. Our results have led to a deeper understanding of the genetic architecture of the regulation of gene expression.

Reported by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
OXFORD
United Kingdom
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