Community Research and Development Information Service - CORDIS

Final Activity Report Summary - MIND (Minimally Invasive Neurostimulation Device)

The MIND Transfer of Knowledge project was centred on neuro-stimulation/neuro-sensing devices for treatment of neurological disorders. Such devices have the potential to provide symptom relief to millions of patients suffering from brain disorders, and for whom systemic drug treatments provide insufficient symptom reduction and/or lead to unacceptable side effects. The major aim of MIND was to develop at Philips Research the scientific expertise for realising novel neuro-technologies that may lay the foundation for next generation neurostimulation and neuro-sensing devices.

MIND has successfully met this goal and contributed amongst others to the realisation of:
Process development of novel thin-film technology using proven fully biocompatible materials (parylene-C, platinum).
High-resolution neural probes for recording and stimulation and that have been tested successfully in vitro and in vivo;
Computer models of stimulation field steering techniques that have been integrated in image-guided neuro-stimulation programming software prototype.
Integrated finite-element models and computational neuronal models for computer simulations of neuronal sensing with high-resolution probes.
Circuit models and theoretical analysis of attainable performance (power consumption, noise performance, band width) of neural sensing circuitry.
First designs of low-noise multi-channel neural-sensing circuitry, implemented in CMOS025 integrated chip technology.

Thus, MIND has successfully contributed to establishing best-in-class neural engineering capability at Philips Research. Several proof-points exist that indicate this knowledge transfer will have sustained impact on Philips Research' scientific capabilities:
The developed neuro-technology capabilities will be applied in new application domains, initially not foreseen prior to MIND (e.g. cochlear implant electrodes, tip-of-catheter active electronics, etc).
The MIND project has contributed to the realisation of next-generation DBS devices that will be brought to market in a spin-off daughter company (Sapiens) established by Philips Research.
Two out of three Fellows have been offered (and accepted) a position at Philips Research and will expand the MIND knowledge to other (i.e. above mentioned) application domains.
An active research programme continues to exist within Philips Research for the further development of DBS technology (in collaboration with Sapiens).

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