Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

Final Activity Report Summary - ELSIC (Enhancement of the Life Science Interface Group Capabilities)

There is tremendous potential for development and use of innovative advanced ICT technologies at the interface between information technologies and other disciplines described collectively as life science research. These range from miniaturisation and non-lab based versions of well-known techniques to the development of new methods and tools allowing for example 'point of care' diagnostics and less invasive implants to be fabricated. This multi-disciplinary research integrating life sciences is a growing are of research and merging the skills of ICT technologies and biotechnologies has been identified as an important objective both for research and commercial development.

The Life Science Interface (LSI) group at Tyndall National Institute (TNI) is a multi-disciplinary team, whose core interest lies in integrating life sciences with microelectronic derived capabilities. The major objective of the ELSIC project is to recruit four experienced post doctorate research fellows with a diverse range of skills, who will ultimately aid in expanding the multi-disciplinary area of the LSI group at TNI. The LSI group has the strategic aim to expand and learn new skills and techniques that will help establish their knowledge and research capabilities that will further enhance their ability to collaborate on the international stage. This will facilitate the LSI group to develop and qualify underlying key technologies to enable interfacing to DNA, proteins and cells for in vitro and later for in vivo applications including the generation of biomedical devices.

The ELSIC programme is intended as a two-way transfer of knowledge (TOK) with recruited researchers also gaining substantial knowledge on various biosytem, microelectronic and fabrication techniques available at TNI. The knowhow of such researchers and the expertise of TNI in the fabrication and design of devices will strengthen the LSI groups research and it is envisaged that this will allow for further projects to be established.

The four recruited research fellows are working in the fields outlined in the four work packages in the proposal. These were;
WP1 - Electrochemical applications - Dr Jorg Strutwolf.
WP2 - Optical bio-systems - Dr Charles Cranfield.
WP3 - FDA regulations - Dr Carlos de la Rosa.
WP4 - Electrophysiology techniques - Dr Matthias Gerhardt.
Each research fellow was assigned a project work package to work on. The objective of WP1 which was led by Dr Strutwolf was to develop a variety of electronic sub-systems for the Chemical MicroAnalytics and Bionics teams within the LSI group. Dr Strutwolf was extremely successful with his assignment and was able to publish many papers on his research.
WP2, which was led by Dr Cranfield had the objective to develop optical detection systems based on Geiger Mode Avalanche Photodiodes. The research done by Dr Cranfield enhanced the on-going activities which were currently being undertaken by the BioAnalytical Microsystems and Nanobiotechnology teams in the LSI group.
WP3, led by Dr de la Rosa had the strategic objective to research all the FDA/ISO regulations associated with biomedical devices and to teach and train staff these regulations. This was an excellent outcome from the ELSIC project as it enabled staff members to be updated on these regulations and this task greatly benefited and enhance the regulatory knowledge of team members within the LSI group.
WP4 lead by Dr Gerhardt had the objective to build a laboratory for electrophysiological research. The goal of the electrophysiological laboratory was to perform in vitro tests for new medical devices capable for stimulating and recording nerve cells. Dr Gerhardt was very successful with establishing this laboratory. A further objective of this project was for experienced researchers working at Tyndall to travel to partner institutes for the acquisition of new knowledge to be transferred and developed by them on their return to TNI. The idea was that these staff members would travel to different institutes in order to gain knowledge in different life science areas and later to transfer this knowledge by training and teaching other staff members.

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