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For multiple uses of oligosaccharides

A French company developed a novel method for the synthesis of new compounds of oligosaccharides grafted on various supports for multiple uses. This one-step technique allows high yields of compounds to be used in wide spread applications from affinity chromatography to gene transfection.
For multiple uses of oligosaccharides
Oligosaccharides are carbohydrate compounds that yield a relatively small number of monosaccharide molecules on complete hydrolysis and these valuable substances are widely used in many applications. For instance, they may be used in affinity chromatography, a useful chemical technique for investigating the interaction between a carbohydrate binding protein and its ligands. Among its key applications, affinity chromatography is used for the screening and separation of natural ligands from complex biological mixtures. This involves detection, purification and determination of the binding ability of a carbohydrate ligand from bodily fluids.

The ever increasing need for the high production of oligosaccharides has motivated a French company to develop a simple, high yielding technique for oligosaccharides derivatives. The process involves very few steps whereby the oligosaccharides bind on a specific intermediate structure that grafts on very different supports that offer multiple oligosaccharides derivatives. Taking advantage of an unusual reactivity of the intermediate structure, the latter comprises a nitrogen atom attached on a carbon atom of a carbonyl (C=O) group. Coupled with one or more functional groups carried on the same group, the structure is capable of fixing this structure on various supports.

With a very high yielding of the order of almost 100% the derived compounds exhibit increased potential for various uses. This novel method allows the production of a large variety of increasingly specific molecules to be used in particular applications. Apart from affinity chromatography, other applications involve gene transfection, cytology, histology, peptide transloading, therapeutic targeting, receptor characterisation, purification, and protein glycosylation. The company is looking for licensing worldwide development and commercialisation rights for its new compounds and production methods.
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