Community Research and Development Information Service - CORDIS

New antioxidant compounds from fungal source

Oxidative stress at the molecular level is a dangerous state, which can often induce cellular damage and lead to specific pathologies.
New antioxidant compounds from fungal source
Diseases such as cancer and Alzheimer's disease have been often linked to oxidative damage and it is therefore important to develop novel therapeutics, which can protect tissues from oxidative stress. Oxidative damage is carried out by reactive oxygen species and can affect changes on DNA and protein structures.

A Spanish-based research team has isolated a new class of compounds that can be used for the treatment of pathologies associated with oxidative damage. Researchers have devised methods to isolate these compounds from liquid culture; there is also a new synthetic procedure for their production. These novel antioxidant compounds have been derived from the fungal species Colletotrichum gloeosporioides.

Patent protection for these compounds and the related methods and procedures has already been applied for. The new methods that have been developed could signal the starting point for a broader antioxidant research project, with application in a variety of diseases and in a variety of industrial settings.

Researchers are therefore keen to form license agreements or other forms of collaboration with pharmaceutical or food companies. Industrial partners are called upon to examine the potential of this group of compounds and exploit it further.
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