Community Research and Development Information Service - CORDIS

Genetic modification of parvovirus

Modification of the genomes of parvoviruses H-1 and MVM, attempting to make them suitable linear vectors, has resulted in:
production of recombinant parvoviruses showing transduction specificity for oncogene-transformed cells and having potential for cancer gene therapy;
programmed cell killing by means of inducible clones of parvoviral genes encoding nonstructural proteins;
demonstration and unravelling of the oncolytic activity of parvoviruses, raising prospects of anticancer applications.

Reported by

Deutches Krebsforchungszentrum
Im Neuenheimer Feld 242
69120 Heidelberg
Germany
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