Community Research and Development Information Service - CORDIS



Project ID: 37637
Country: Netherlands

Taking genomic action against Chlamydia

Chlamydia trachomatis (CT) represents a very serious challenge to global healthcare being a major sexually transmitted disease (STD) and one of the major causes of blindness. European research has taken a genomic approach to tackling the disease.
Taking genomic action against Chlamydia
CT is the cause of the most prevalent STD worldwide. Left untreated, CT infection can cause pelvic inflammatory disease, ectopic pregnancy and infertility. With almost 100 million new cases every year, health and research authorities are keen to find new tools for detection and treatment of the disease.

Twin studies have reported that there is an overall 40 % genetic predisposition to CT infections and the EU-funded 'Contribution of molecular epidemiology and host-pathogen genomics to understand Chlamydial trachomatis disease' (Epigenchlamydia) project aimed to develop tools to determine predisposition on an individual basis as well as risk of development of complications. Viewing the threat of CT globally, project scientists also planned research to develop processes for the detection and treatment of CT, including the possibility of vaccines.

Epigenchlamydia achieved a high standard of research results. Work completed by the consortium was selected by the international network Genome-based Research and Population Health as a best practice example for the development of diagnostic tools for the benefit of public health.

the project consortium also worked in close collaboration with the Public Health Agency of Canada. Together, they arranged a high-profile meeting held in Maastricht, the Netherlands to heighten political awareness of the importance of CT in public health.

epigenchlamydia was aware of the need to translate their results from the lab into public health policy. To this end, they worked alongside the Public Health Genomics European Network (PHGEN). As PHGEN represents a cornerstone of the development of genomics in the sphere of public health, the research results will be incorporated in the body's future publications.PHGEN have produced the first edition of 'European best practice guidelines for quality assurance, provision and use of genome-based information and technologies'. This comprehensive document will assist European health authorities to integrate genomic-based information and technologies into public health systems.

project researchers working under the umbrella of Epigenchlamydia have raised awareness on the serious health issues presented by CT to relevant European authorities. Results of their research are being incorporated into the dynamic setting of genomic- and proteomic-applied public healthcare.

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