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NEMAGENETAG — Result In Brief

Project ID: 503334
Country: Greece

C. elegans as a model for human diseases

Human cell biology and neurobiology aspects can be studied in model systems such as Caenorhabditis elegans, which possesses genome similarity with humans. EU experts and pioneers in the study of the nematode collaborated to establish it as a perfect model to dissect human pathologies.
C. elegans as a model for human diseases
The high homology of nematode C. elegans' genes to those involved in human disease makes it a potent model to study human pathologies. Therefore, using this organism as a model system will allow the study of a important human biological processes and their molecular mechanisms.

The EU-funded project ‘Nematode gene-tagging tools and resources’ (Nemagenetag) focused on the development of advanced tools and the collection of appropriate resources in order to use C. elegans as a human pathologies model.

Researchers generated and evaluated an enormous collection of mutants. Almost the complete genome of approximately 20 000 genes was subject to change using optimised and novel mutagenesis methodologies. The required infrastructure for automatic managing and maintaining of this collection was established within the project.

The result of this project was the creation of a comprehensive collection of characterised mutant strains and optimised tools for mutagenesis and transgenesis in C. elegans. Relevant project information and tools have been made readily available to the European and international scientific community. The direct as well as the long-term impact of Nemagenetag in the key field of functional genomics is tremendous and directly relevant to pharmaceutical research and development.

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