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INTERDEVO — Result In Brief

Project ID: 5139
Country: Spain

The molecular basis of psychiatric disorders

Complex interneuron networks in the cerebral cortex (CC) maintain the physiological function of the human brain. European scientists shed light on these complex neuronal networks in order to understand the molecular basis of related psychiatric disorders.
The molecular basis of psychiatric disorders
The CC is a layer of neural tissue that covers the cerebrum of the mammalian brain. The neural assembly in CC constitutes one of the most complex neuronal systems in the brain, forming essential functional networks of two interacting neuronal types.

A variety of psychiatric disorders, including epilepsy, schizophrenia and bipolar disorder, are associated with problematic interneuron function in CC. The key towards uncovering the mechanisms that lead to these disorders is a deep understanding of cortical neuronal system composition and development. Despite the impressive images of cortical neuron development in high resolution, the underlying mechanisms are poorly understood.

In order to obtain a comprehensive description of the cellular and molecular mechanisms responsible for the development of cortical interneurons, the EU-funded project Interdevo was initiated. A network of European scientists was established applying a multidisciplinary strategy, based on novel cutting-edge technologies, including bioinformatics, genomics applications, imaging, and cellular and molecular biology. Furthermore, new mouse models of cortical disorders involving interneuron deficiency were developed.

Interdevo was successful in accomplishing all of its objectives, which generated new insights into the field of cortical interneuron and related disorders. The generated knowledge was disseminated in numerouspublications, patents and new technologies, which were made available to the scientific community.

The major achievements of the project include new insights into the mechanisms of cortical interneuron specification, patterning and migration, as well as their genetic determinants. In addition, new technologies and research tools were developed and made available to the scientific society.

Knowledge and the technology generated by Interdevo will significantly impact the improvement of diagnosis and treatment of human cortical developmental disorders.

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