Community Research and Development Information Service - CORDIS

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Characterisation of single molecule dynamics within HIV-1 reservoirs as a target for interference with virus persistence and immune evasion
ID: 793830
Start date: 2019-01-01, End date: 2020-12-31
Human Immunodeficiency Virus type 1 (HIV-1) remains a significant cause of comorbidity and mortality around the world. One of HIV-1 persistence and immune evasion mechanisms is the ability to create hidden virus reservoirs in cells. These virus reservoirs, termed...
Programme: H2020-EU.1.3.2.
Record Number: 215204
Last updated on: 2018-06-06
HIV-1 acquisition and the future of prevention strategies: deciphering the eclipse phase through modelling and phylogenetics
ID: 757688
Start date: 2018-03-01, End date: 2023-02-28
The HIV eclipse phase typically refers to the time between a virus entering a sexually exposed person and detection of viral RNA in their plasma. Of the four phases of HIV-1 infection (eclipse, acute, chronic and AIDS), the eclipse phase is currently the only window of...
Programme: H2020-EU.1.1.
Record Number: 213391
Last updated on: 2018-02-16
Analysing the migration choices of HIV-positive gay men in England and France
ID: 747110
Start date: 2018-03-01, End date: 2020-02-29
Despite improvements in available therapies and investments in prevention campaigns, HIV-rates continue to rise across European cities. Gay men are over-represented amongst people with HIV, thus experiencing the combined effects of homophobia and HIV-related stigma. Several...
Programme: H2020-EU.1.3.2.
Record Number: 209239
Last updated on: 2017-03-20
Structural and functional characterization of large viral and human non-coding RNA motifs involved in HIV infection
ID: 748759
Start date: 2018-09-01, End date: 2020-08-31
HIV infections cause 1.2Mi deaths/year worldwide at steadily-increasing rates, partly because of antiretroviral resistance and the impossibility of eradicating latent viruses. To expand our understanding of HIV pathogenesis, we need to unravel all molecular mechanisms involved...
Programme: H2020-EU.1.3.2.
Record Number: 210076
Last updated on: 2017-04-21
Development of the Cyclin-Dependent Kinase Inhibitor VS2-370 to Target HIV-associated Malignancies and to Purge Viral Reservoir
ID: 762583
Start date: 2017-03-01, End date: 2017-07-31
ViroStatics, operating in the biotechnology industry, is developing the innovative drug VS2-370 that targets both HIV-associated cancer and its indirect cause, the viral infection. There is no similar drug, as HIV infection and associated malignancies are presently treated...
Programme: H2020-EU.2.1.4.
Record Number: 208161
Last updated on: 2017-07-26
Glucose metabolism and mTOR pathway role in CD8+ T cell control of HIV-1
ID: 706871
Start date: 2016-04-01, End date: 2018-03-31
Antiretroviral therapy can decrease HIV-1 below the limit of detection but fails to eliminate the virus completely. One of the main goals of a HIV-1 vaccine is the generation of cytotoxic CD8 T cell responses that counteract the virus. CD8 T cells participate in the control of...
Programme: H2020-EU.1.3.2.
Record Number: 201464
Last updated on: 2017-08-05
Accelerating HIV Cure in Europe
[PROJECT] EU4HIVCURE - Accelerating HIV Cure in Europe
ID: 691119
Start date: 2016-02-01, End date: 2020-01-31
Finding a CURE for 35 Million individuals living with HIV/AIDS is one of the great global health challenges of the 21st century. The major obstacle to HIV eradication is the persistence of latent HIV cellular reservoirs, where the integrated viral genome is transcriptionally...
Programme: H2020-EU.1.3.3.
Record Number: 199940
Last updated on: 2016-06-30
HIV-1 sensing and signaling in dendritic cells
ID: 670424
Start date: 2015-10-01, End date: 2020-09-30
HIV-1 is a major global health problem with over 2 million new infections every year, and although antiretroviral therapy is effective, chronic infected patients suffer from severe co-morbidities due to immune dysfunction. With the proposed SENTINEL project, I aim to identify...
Programme: H2020-EU.1.1.
Record Number: 198710
Last updated on: 2017-01-09
European AIDS Vaccine Initiative 2020
ID: 681137
Start date: 2015-11-01, End date: 2020-10-31
HIV-1 is responsible for a global pandemic of 35 million people, and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the...
Programme: H2020-EU.3.1.2.
Record Number: 198798
Last updated on: 2017-08-17
HIV/SIV exploits DCs in mucosal infection: mechanisms of transmission and modulation by semen associated factors
ID: 658277
Start date: 2015-07-01, End date: 2017-06-30
Worldwide a large proportion of all new cases of HIV-1 infection are due to anal sexual intercourse, being the anal/rectal as well as distal colonic mucosa a site of viral uptake and entry. I recently demonstrated that intestinal lamina propria resident DCs migrate towards and...
Programme: H2020-EU.1.3.2.
Record Number: 195582
Last updated on: 2017-06-23
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List retrieved on: 2018-08-19
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