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[REPORT SUMMARY] IMPROVE Data Library
The IMPROVE Data Library consists of digital recordings of continuous monitored signals, clinical patient data and continuous patient state annotations. The continuous signals recorded typically are ECG (2 channels), systemic blood pressure, pulmonary arterial pressure, centra...
Programme: FP4-BIOMED 2
Record Number: 23184
Last updated on: 1999-09-28
By using the method developed it is possible to determine the rate of methylation catalyzed by the enzyme catechol O-methyltransferase practically for any catechol-type substrate. A new chromatographic catechol O-methyltransferase (COMT) assay based on S-adenosyl-L-[methyl-14...
Programme: FP4-BIOMED 2
Record Number: 26761
Last updated on: 2001-07-30
The expression of two human UDP-glucuronosyltransferase isoenzymes in Semliki Forest virus expression system provides the means of producing large quantities of recombinant enzyme for enzyme kinetic determinations. Protocols and methods for the expression of human UDP-glucuro...
Programme: FP4-BIOMED 2
Record Number: 26759
Last updated on: 2001-07-30
The 1-hydroxypyrene UGT method provides a novel tool for quantifying extremely low UGT activities in the human liver as well as in other tissue specimens. This in vitro glucuronidation reaction is preferentially catalyzed by the human recombinant UGT1A6 and UGT1A9 isoforms. On...
Programme: FP4-BIOMED 2
Record Number: 26756
Last updated on: 2001-07-30
The systems were characterised systematically for their substrate specificity and kinetics, level of expression of drug metabolising enzymes, at both the RNA and protein level, and their responses to inducing compounds as appropriate. Where necessary, specific reagents, such a...
Programme: FP4-BIOMED 2
Record Number: 23361
Last updated on: 2001-08-09
The described co-culture test system can be used to reveal the potential oculotoxicity of new drugs which need metabolic activation before they exert toxicity. Most of drugs fall into this category. The possibility to use human primary hepatocytes as activator cells allows thi...
Programme: FP4-BIOMED 2
Record Number: 26758
Last updated on: 2001-07-30
ID: BMH4983202
Start date: 1998-05-01, End date: 2001-04-30
Objectives The objectives of the application are to understand what factors control phospholipid hydroperoxide glutathione peroxidase (PHGPX EC.1.11.1.12) expression at transcriptional level, what factors are necessary for the overexpression of PHGPX and what is the effect of ...
Programme: FP4-BIOMED 2
Record Number: 47631
Last updated on: 2002-11-25
ID: BMH4983605
Start date: 1998-11-01, End date: 2002-03-31
Ankylosing Spondylitis (AS) and other spondylarthropathies (SPA) are the second most frequent cause of chronic inflammatory rheumatisms and represent a socio-economic burden. The genetic predisposition is strongly linked to the MHC complex HLA-B27 gene but other loci are als...
Programme: FP4-BIOMED 2
Record Number: 46751
Last updated on: 1999-04-15
ID: BMH4989596
Start date: 1999-01-01, End date: 2000-12-31
Surgical robotics is a rapidly growing economic field. More and more are developing robots for hip and knee replacement, guiding surgical instruments, holding microscopes or endoscopes. In Europe almost 6000 hospitals may buy one or more. On the other hand, surgical robots a...
Programme: FP4-BIOMED 2
Record Number: 46775
Last updated on: 1999-04-15
ID: BMH4983373
Start date: 1998-05-01, End date: 2001-04-30
Objectives The overall objective of this proposal is to investigate the role of alterations in expression and function of central and renal a2-AR subtypes in the development and/or maintenance of hypertension. This objective is informed by the established hypothesis that dysfu...
Programme: FP4-BIOMED 2
Record Number: 47640
Last updated on: 2002-11-18
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