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Towards evidence-based genomic medicine: filling the evidence gaps through modelling studies
ID: 310884
Start date: 2014-01-01, End date: 2018-12-31
At increasingly high rate, genome-wide association and whole genome sequencing studies unravel genetic variants implicated in common diseases such as coronary heart disease, cancer, dementia and type 2 diabetes. One of the major promises is that these advances will lead to mo...
Programme: FP7-IDEAS-ERC
Record Number: 111046
Last updated on: 2017-03-13
Targeting downstream effectors of Wnt signaling in colorectal cancer
ID: 311301
Start date: 2012-11-01, End date: 2017-10-31
Colorectal cancer (CRC) is one of the most common cancers of the western world. The underlying initiating mutation for the majority of CRC is within the Adenomatous Polyposis Coli (Apc) gene. The APC protein performs an important role in controlling the levels of Wnt signalli...
Programme: FP7-IDEAS-ERC
Record Number: 105561
Last updated on: 2016-03-31
Macroecological studies of long-term historical constraints on functional diversity and ecosystem functioning across continents
ID: 310886
Start date: 2013-01-01, End date: 2017-12-31
"Earth’s environment is ongoing massive changes with strong impacts on ecosystems and their services to human societies. It is thus crucial to improve understanding of ecosystem functioning and its dynamics under environmental change. I propose to do this by assessing the nov...
Programme: FP7-IDEAS-ERC
Record Number: 105926
Last updated on: 2015-03-11
Order in Disorder: Context-dependent strategies for integrating peptide-mediated interactions
ID: 310873
Start date: 2012-12-01, End date: 2017-11-30
Peptide-mediated protein interactions are emerging as key regulators of many important regulatory processes in the cell. Short motifs, usually embedded into disordered regions of the protein, interact with specific sets of protein partners in a transient way and allow efficie...
Programme: FP7-IDEAS-ERC
Record Number: 105647
Last updated on: 2016-08-29
Following the Genomic Footprints of Early Europeans
ID: 311413
Start date: 2012-10-01, End date: 2017-09-30
Two of greatest challenges of the post-genomic era are to (i) develop a detailed understanding of the heritable variation in the human genome, and to (ii) determine which key events in human evolutionary history that are responsible for patterns of genomic variation. The rece...
Programme: FP7-IDEAS-ERC
Record Number: 105331
Last updated on: 2017-10-06
Phase contrast X-ray imaging for medicine
ID: 310005
Start date: 2012-11-01, End date: 2017-10-31
The goal of this grant is to introduce grating-based phase contrast enhanced X-ray imaging as a novel diagnostic tool in human medicine. We will first gain fundamental knowledge to master high-energy grating-based phase contrast imaging and develop novel radiological equipmen...
Programme: FP7-IDEAS-ERC
Record Number: 105715
Last updated on: 2016-03-31
Laser: driving force for a new generation of hearing aids
ID: 311469
Start date: 2012-10-01, End date: 2018-05-31
This proposal presents an unconventional method for the stimulation of the outer and middle ear that may change the current concept of hearing aids. Photons of the visible light are known to activate the visual sensory cells through photoreceptors. However, when the so-called...
Programme: FP7-IDEAS-ERC
Record Number: 105124
Last updated on: 2017-03-27
Unveiling the Molecular Basis of RNA Interference with Single Molecule Fluorescence
ID: 309509
Start date: 2012-09-01, End date: 2017-08-31
Recent groundbreaking discoveries have changed our view on RNA from that of a passive information carrier to an important regulatory element. MicroRNA is a small regulatory RNA that controls nearly all mRNAs in eukaryotic cells. Since this regulation process (termed RNA inter...
Programme: FP7-IDEAS-ERC
Record Number: 104724
Last updated on: 2016-03-31
Anatomical and Functional Dissection of Neural Circuits in the Zebrafish Optic Tectum
ID: 311159
Start date: 2013-01-01, End date: 2018-06-30
The optic tectum has emerged as a tractable visuomotor transformer, in which anatomical and functional studies can allow a better understanding of how behavior is controlled by neuronal circuits. We plan to examine the formation and function of the visual system in zebrafish ...
Programme: FP7-IDEAS-ERC
Record Number: 106304
Last updated on: 2017-09-24
Innate sensing of HIV and immune responses
ID: 309848
Start date: 2013-01-01, End date: 2017-12-31
Since its isolation in 1983 as a causative agent of AIDS, HIV-1 has remained an exceptional challenge. The human immune system usually ultimately fails at controlling infection by the virus. In contrast, most individuals infected with the related and poorly studied lentivirus...
Programme: FP7-IDEAS-ERC
Record Number: 106324
Last updated on: 2016-11-23
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List retrieved on: 2018-08-21
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