Community Research and Development Information Service - CORDIS

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Understanding the development and function of cerebral cortex folding
ID: 309633
Start date: 2013-01-01, End date: 2018-06-30
The mammalian cerebral cortex was subject to a dramatic expansion in surface area during evolution. This process is recapitulated during development and is accompanied by folding of the cortical sheet, which allows fitting a large cortical surface within a limited cranial vol...
Programme: FP7-IDEAS-ERC
Record Number: 105577
Last updated on: 2017-08-27
Dissection of centromeric chromatin and components: A biosynthetic approach
ID: 311674
Start date: 2013-02-01, End date: 2019-01-31
The centromere is one of the most important chromosomal elements. It is required for proper chromosome segregation in mitosis and meiosis and readily recognizable as the primary constriction of mitotic chromosomes. Proper centromere function is essential to ensure genome stab...
Programme: FP7-IDEAS-ERC
Record Number: 106164
Last updated on: 2017-08-22
Bacterial effector secretion: Function and Architecture of the Type 3 Secretion System
ID: 311374
Start date: 2013-01-01, End date: 2017-12-31
Bacterial pathogens secrete effector proteins to manipulate host cells during infection. In Gram-negative bacteria the conserved type 3 secretion system (T3SS) delivers effector proteins to the host cell in a spatiotemporal manner. Although major T3SS constituting components ...
Programme: FP7-IDEAS-ERC
Record Number: 105833
Last updated on: 2017-08-13
From mesoderm to hematopoietic stem cell commitment: cellular and molecular events occuring during mouse embryonic development
ID: 309361
Start date: 2013-03-01, End date: 2018-02-28
Hematopoietic Stem Cells (HSCs) are at the origin of all blood cells needed throughout life. HSC transplantation is used to treat patients with blood related disorders. However, the number of HSCs available for clinic and research remains limited. The production of large quan...
Programme: FP7-IDEAS-ERC
Record Number: 107035
Last updated on: 2017-08-13
The Molecular Communication Mechanism of Motor Neuron Survival and Synapse Maintenance
ID: 309377
Start date: 2013-02-01, End date: 2019-01-31
In order to survive and maintain normal function, the cell depends on a dynamic system of spatial specificity and fidelity of signaling pathways that can respond to both internal and external changes over space and time. This cell-cell communication is mediated by ligand-rece...
Programme: FP7-IDEAS-ERC
Record Number: 106160
Last updated on: 2017-07-02
Fine Tuning the Final Common Pathway: Molecular Determinants of Motor Unit Development and Plasticity
ID: 311710
Start date: 2012-11-01, End date: 2017-10-31
Motor neurons (MNs) constitute the final common pathway in the generation of behaviors by linking the CNS with the movement apparatus. Herein, MNs diversify into fast, intermediate and slow types whose properties are tuned to the speed, force and endurance of the muscle fiber...
Programme: FP7-IDEAS-ERC
Record Number: 105218
Last updated on: 2017-06-26
Fitness drivers in long-distance migrants: the interacting roles of physiology, social biology, ecological and physical environments
ID: 310820
Start date: 2013-02-01, End date: 2019-01-31
Long distance migration in birds is among the most dramatic and exciting phenomena in nature. However despite many years of study, there are still huge gaps in our understanding of how this behaviour shapes individual ecology and influences population processes. For example, ...
Programme: FP7-IDEAS-ERC
Record Number: 106595
Last updated on: 2017-06-26
SUMOrice: Exploiting an emerging protein modification system, SUMOylation to boost rice yield during drought and salt stress
ID: 310235
Start date: 2013-04-01, End date: 2019-03-31
"To feed 9 billion people by 2050 is an unprecedented challenge. Rice is the food source for the majority of the world's population but also a model for cereals. Drought and related high salinity during essential periods of plant growth affects nearly all crops including the ...
Programme: FP7-IDEAS-ERC
Record Number: 107495
Last updated on: 2017-06-21
Reverse engineering the vertebrate molecular machinery for magnetic biomineralisation
ID: 311552
Start date: 2013-01-01, End date: 2017-12-31
In order to understand distributed biological networks and invent effective molecular therapies, we need to be able to image and control molecular processes across entire live organisms. Although an arsenal of genetically encoded fluorescent sensors and light-activated protei...
Programme: FP7-IDEAS-ERC
Record Number: 106439
Last updated on: 2017-06-12
Biochemical reconstitution of DNA repair reactions on physiological chromatin substrates
ID: 311336
Start date: 2013-01-01, End date: 2018-12-31
For cells and organisms to survive and propagate, they must accurately pass on their genetic information to the next generation. Errors in this process may arise from spontaneous mistakes in normal cellular metabolism, or from exposure to external agents, such as chemical mut...
Programme: FP7-IDEAS-ERC
Record Number: 105906
Last updated on: 2017-06-05
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List retrieved on: 2018-08-22
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