Community Research and Development Information Service - CORDIS

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Factor XII and the contact system: 
cross-talk between thrombosis and inflammation
ID: 311575
Start date: 2013-08-01, End date: 2018-07-31
Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. This system starts a cascade of proc...
Programme: FP7-IDEAS-ERC
Record Number: 109422
Last updated on: 2018-01-22
Next generation sequencing for detection of human primary immunodeficiency syndromes characterized by impaired cytotoxic lymphocyte function
ID: 311335
Start date: 2013-05-01, End date: 2018-04-30
Human primary immunodeficiencies affecting cytotoxic lymphocyte function are associated with high morbidity and mortality. They often present as hyperinflammatory syndromes triggered by viral infections, hematological malignancies, or systemic autoimmunity. Although recent ad...
Programme: FP7-IDEAS-ERC
Record Number: 108234
Last updated on: 2018-01-22
Regulation of gene expression and cell fate by DNA (hydroxy)methylation
ID: 309384
Start date: 2013-10-01, End date: 2018-09-30
(Hydroxy)methylation of cytosine residues in eukaryotic DNA represents a major means to regulate gene expression during development. These modifications are considered to be epigenetic marks, since they have a profound impact on phenotype, but are inherited from mother to dau...
Programme: FP7-IDEAS-ERC
Record Number: 105899
Last updated on: 2018-01-22
The role of CpG island RNAs and Polycomb-RNA interactions in developmental gene regulation
ID: 311704
Start date: 2013-09-01, End date: 2019-04-30
A great challenge in developmental biology research has been to understand how cell type specific expression programs are orchestrated through regulated access to chromatin. The interaction between non-coding RNAs and chromatin regulators is emerging as an exciting new resear...
Programme: FP7-IDEAS-ERC
Record Number: 109713
Last updated on: 2018-01-03
Bacterial Cell Morphogenesis
[PROJECT] BACEMO - Bacterial Cell Morphogenesis
ID: 311231
Start date: 2013-02-01, End date: 2019-01-31
In bacteria, the though external cell wall and the intracellular actin-like (MreB) cytoskeleton are major determinants of cell shape. The biosynthetic pathways and chemical composition of the cell wall, a three dimensional polymer network that is one of the most prominent tar...
Programme: FP7-IDEAS-ERC
Record Number: 105022
Last updated on: 2017-12-18
The Origin of Jawed Vertebrates and the Evolution of Morphology in Deep Time
ID: 311092
Start date: 2013-01-01, End date: 2018-12-31
Jawed vertebrates account for more than 99% of modern vertebrate diversity. Collectively, they comprise chondrichthyans (sharks, rays, and chimaeras) and osteichthyans (bony fishes and terrestrial vertebrates, including humans). The anatomy of jawed vertebrates includes a ser...
Programme: FP7-IDEAS-ERC
Record Number: 105578
Last updated on: 2017-12-18
Nano-Sensitizer Cancer Cell Targeted Radiotherapy
ID: 310985
Start date: 2013-04-01, End date: 2019-02-28
Targeted chemotherapy in combination with external beam radiation therapy (radiotherapy) is a promising approach to significantly improve the therapeutic outcome for cancer patients. To achieve this, it is essential to develop drug delivery technology that specifically delive...
Programme: FP7-IDEAS-ERC
Record Number: 107036
Last updated on: 2017-12-18
Priming of plant immunity: from its onset to trans-generational maintenance
ID: 309944
Start date: 2013-01-01, End date: 2017-12-31
Plant defence depends on speed: the sooner a plant recognises its attacker, the more effective its defence response will be. Over the course of evolution, plants have acquired the ability to prime their immune system after perception of specific environmental signals. This he...
Programme: FP7-IDEAS-ERC
Record Number: 104861
Last updated on: 2017-12-18
Functional protein dynamics studied 
by solution- and solid-state NMR spectroscopy
ID: 311318
Start date: 2013-04-01, End date: 2019-01-31
Proteins are highly flexible objects that perform their functions by sampling a wide range of conformations. The characterization of such motions is, therefore, crucial to establish the link between protein structure and function. In this project we will use advanced nuclear ...
Programme: FP7-IDEAS-ERC
Record Number: 107661
Last updated on: 2017-12-11
The analysis of mitochondrial dynamics in ageing and neurodegeneration
ID: 309742
Start date: 2013-01-01, End date: 2018-12-31
The survival of our most active tissues, such as the brain and heart, throughout decades of a human lifespan presents an extraordinary biological challenge. Mitochondria are central to the life and death of these tissues. They provide the cellular energy required by these cel...
Programme: FP7-IDEAS-ERC
Record Number: 105785
Last updated on: 2017-12-11
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List retrieved on: 2018-02-24
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