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Results 1 - 10 of 66
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Factor XII and the contact system: 
cross-talk between thrombosis and inflammation
ID: 311575
Start date: 2013-08-01, End date: 2018-07-31
Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. This system starts a cascade of proc...
Programme: FP7-IDEAS-ERC
Record Number: 109422
Last updated on: 2018-01-22
Next generation sequencing for detection of human primary immunodeficiency syndromes characterized by impaired cytotoxic lymphocyte function
ID: 311335
Start date: 2013-05-01, End date: 2018-04-30
Human primary immunodeficiencies affecting cytotoxic lymphocyte function are associated with high morbidity and mortality. They often present as hyperinflammatory syndromes triggered by viral infections, hematological malignancies, or systemic autoimmunity. Although recent ad...
Programme: FP7-IDEAS-ERC
Record Number: 108234
Last updated on: 2018-01-22
Priming of plant immunity: from its onset to trans-generational maintenance
ID: 309944
Start date: 2013-01-01, End date: 2017-12-31
Plant defence depends on speed: the sooner a plant recognises its attacker, the more effective its defence response will be. Over the course of evolution, plants have acquired the ability to prime their immune system after perception of specific environmental signals. This he...
Programme: FP7-IDEAS-ERC
Record Number: 104861
Last updated on: 2017-12-18
Molecular determinants of aphid host range
ID: 310190
Start date: 2013-02-01, End date: 2018-10-31
Many aphid species are restricted to one or few host plants, while some aphids, many of which are of agricultural importance, can infest a wide range of plant species. An important observation is that aphids spend a considerable time on nonhost species, where they probe the l...
Programme: FP7-IDEAS-ERC
Record Number: 105786
Last updated on: 2017-11-20
Nutrient sensing by parasites
[PROJECT] PARASITENUTRISENSING - Nutrient sensing by parasites
ID: 311502
Start date: 2012-12-01, End date: 2017-11-30
As any other obligate parasite, Plasmodium depends on its hosts and on the nutrients they provide to survive and complete its life cycle. Surprisingly, nothing is know about Plasmodium’s capacity to sense nutrients or its host’s nutritional status and thereby reprogram its me...
Programme: FP7-IDEAS-ERC
Record Number: 106248
Last updated on: 2017-11-20
Impact of virus infection on the host proteome
ID: 311339
Start date: 2012-11-01, End date: 2017-10-31
Pathogens exploit cellular resources for their own benefit and their propagation. Co-evolution of viruses and their hosts led to the establishment of very specific interactions between both partners. The balance between both, the viral attack and the cellular defense mechanis...
Programme: FP7-IDEAS-ERC
Record Number: 105790
Last updated on: 2017-11-20
Proliferation and Migration under External Constraints
ID: 311205
Start date: 2013-01-01, End date: 2018-06-30
Cell proliferation lies at the heart of the threat posed by tumours. It involves cellular growth, division and migration. The tissue surrounding a tumor physically limits its proliferation, which implies that cells that are able to produce effective tumour growth, as well as ...
Programme: FP7-IDEAS-ERC
Record Number: 106353
Last updated on: 2017-09-24
Endosomal dependent transport to the unique secretory organelles of apicomplexan parasites
ID: 309255
Start date: 2013-02-01, End date: 2019-01-31
Apicomplexan parasites invade the host cell in an active process that involves gliding motility, formation and movement through the moving junction (MJ) and establishment of a prasitophorous vacuole (PV) around the parasite. In order to invade the host cell they employ an ars...
Programme: FP7-IDEAS-ERC
Record Number: 105401
Last updated on: 2017-09-10
NutrImmune: Nutrient-controlled molecular pathways instructing development and function of mucosa-associated innate lymphocytes
ID: 311377
Start date: 2013-03-01, End date: 2018-02-28
The last decade has witnessed an explosion of research into the molecular networks ensuring maintenance of a mutualistic relationship between microbes and host cell networks at mucosal surfaces. Failure of such homeostatic or adaptive programs lead to susceptibility to intest...
Programme: FP7-IDEAS-ERC
Record Number: 107185
Last updated on: 2017-09-03
Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers
ID: 310917
Start date: 2013-02-01, End date: 2019-01-31
Lymphoid cancers are among the most common human malignancies and characteristically harbour genomic aberrations. Although databases will soon be flooded with genome sequences from thousands of tumours, interpretation and validation of these data is limited by the genetic var...
Programme: FP7-IDEAS-ERC
Record Number: 106163
Last updated on: 2017-08-27
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List retrieved on: 2018-04-24
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