Community Research and Development Information Service - CORDIS

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Role of endoplasmic reticulum in neurodegeneration: physiopathology of a form of hereditary spastic paraplegia as a model
ID: 311149
Start date: 2013-04-01, End date: 2018-03-31
Endoplasmic reticulum (ER) is a dynamic, tubular intracellular network implicated in a variety of cellular functions. Although it is known to play a role in neurodegeneration, its organization and precise function in neurons have been neglected. I will use the physiopathology...
Programme: FP7-IDEAS-ERC
Record Number: 107496
Last updated on: 2016-08-15
Counteracting psychosis by optimizing interaction
ID: 309767
Start date: 2013-04-01, End date: 2018-03-31
Psychotic disorders are amongst the most severe mental disorders. However, current treatments have failed to reduce disability or change the prospects for recovery for patients with a psychotic disorder. In this project, I will investigate an entirely novel therapy, targeting...
Programme: FP7-IDEAS-ERC
Record Number: 107974
Last updated on: 2016-08-15
Autophagy as a cancer treatment
[PROJECT] CANCERPHAGY - Autophagy as a cancer treatment
ID: 311331
Start date: 2012-10-01, End date: 2018-09-30
Cancer is one of the most prevalent human killer diseases. Autophagy, a lysosome-mediated process that degrades cellular components and damaged organelles, has recently emerged as an important player in cancer. Indeed, autophagy inhibition promotes cancer initiation through g...
Programme: FP7-IDEAS-ERC
Record Number: 104727
Last updated on: 2016-08-01
Memory B cell immunity in chronic viral infection
ID: 310962
Start date: 2013-09-01, End date: 2018-08-31
This project aims for a quantum leap in the understudied area of memory B cell immunity to chronic viral infection. It provides i) a landscape analysis of primary and memory B cell responses to chronic viral challenge, ii) investigates receptor hypermutation of memory B cells...
Programme: FP7-IDEAS-ERC
Record Number: 106703
Last updated on: 2016-07-25
Ancient Pathogen Genomics of Re-Emerging Infectious Disease
ID: 310920
Start date: 2013-01-01, End date: 2017-12-31
Here we propose a first step toward a direct reconstruction of the evolutionary history of human infectious disease agents by obtaining genome wide data of historic pathogens. Through an extensive screening of skeletal collections from well-characterized catastrophe, or emerg...
Programme: FP7-IDEAS-ERC
Record Number: 104863
Last updated on: 2016-07-18
Mechanisms that prevent aneuploidy
[PROJECT] NOANEUPLOIDY - Mechanisms that prevent aneuploidy
ID: 311358
Start date: 2013-01-01, End date: 2017-12-31
The mechanisms that safeguard cells against aneuploidy are of great interest as aneuploidy contributes to tumorigenesis. To gain insight into these mechanisms, I studied the behavior of cells entering mitosis with damaged chromosomes. I used the endonuclease I-CreI to generat...
Programme: FP7-IDEAS-ERC
Record Number: 106458
Last updated on: 2016-07-08
The inherent morphological potential of the actin cortex and the mechanics of shape control during cell division
ID: 311637
Start date: 2013-03-01, End date: 2018-02-28
The shape of animal cells is primarily determined by the cellular cortex, a cross-linked network of actin and myosin lying directly beneath the plasma membrane. Although it is increasingly clear that the study of cell mechanics is essential to understand cellular morphogenesi...
Programme: FP7-IDEAS-ERC
Record Number: 107238
Last updated on: 2016-06-20
What makes our subjective perception of the world unique?
ID: 310829
Start date: 2013-02-01, End date: 2018-01-31
We commonly assume that our perception of the world is constant and seamless. This intuition belies the dramatic differences in the perceived quality of a stimulus even within the same individual when it is shown at different spatial locations or different times. Conventional...
Programme: FP7-IDEAS-ERC
Record Number: 106162
Last updated on: 2016-06-20
Neurobiological basis of collective decision making in the human brain
ID: 309865
Start date: 2013-01-01, End date: 2017-12-31
We continually interact with each other & share information to make decisions together as friends, families, committees, juries, interest groups and institutions. The question of how collective decisions are made dates back many centuries and has been vigorously studied in so...
Programme: FP7-IDEAS-ERC
Record Number: 105902
Last updated on: 2016-06-20
Specificity in the ubiquitin system
[PROJECT] UBSPECIFIC - Specificity in the ubiquitin system
ID: 309756
Start date: 2012-10-01, End date: 2017-09-30
Protein ubiquitination is an important posttranslational modification that regulates virtually all cellular processes. Its versatility arises from the ability of ubiquitin to form eight structurally and functionally distinct polymeric chains. It is clear that all chain types ...
Programme: FP7-IDEAS-ERC
Record Number: 105257
Last updated on: 2016-06-20
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List retrieved on: 2018-02-23
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