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Regulation of Gene Expression by non-canonical poly(A) and poly(U) polymerases
ID: 309419
Start date: 2013-02-01, End date: 2019-01-31
In eukaryotes, almost all RNA molecules are processed at their 3’ ends and most mRNAs are polyadenylated in the nucleus by canonical poly(A) polymerases (PAPs). Recently, several new non-canonical poly(A) (ncPAPs) and poly(U) polymerases (PUPs) have been discovered that have ...
Programme: FP7-IDEAS-ERC
Record Number: 106869
Last updated on: 2017-12-07
Learning to read the code of large neural populations
ID: 311238
Start date: 2013-01-01, End date: 2018-10-31
Information is represented and transmitted in the brain by the joint activity of large groups of neurons. Understanding how information is “written” in these population patterns, and how it is read and processed, is a fundamental question in neuroscience. Yet, because of the ...
Programme: FP7-IDEAS-ERC
Record Number: 106484
Last updated on: 2017-12-04
Towards a mechanistic understanding of mRNA localization
ID: 310957
Start date: 2013-01-01, End date: 2018-12-31
The localization of mRNAs has been increasingly recognized as a prominent mode of regulation of gene expression in eukaryotes. Localized RNAs can have crucial roles during animal development, in the maintenance of cell polarity and in nervous system function. Studies of RNA l...
Programme: FP7-IDEAS-ERC
Record Number: 105717
Last updated on: 2017-12-04
Improved Diagnosis and Management of Heart Disease by 4D Blood Flow Assessment
ID: 310612
Start date: 2013-01-01, End date: 2017-12-31
The primary purpose of the cardiovascular system is to drive, control and maintain blood flow to all parts of the body. Despite the primacy of flow, cardiac diagnostics still rely almost exclusively on tools focused on morphological assessment. The objective of the HEART4FLOW...
Programme: FP7-IDEAS-ERC
Record Number: 106001
Last updated on: 2017-12-04
The Structure and Assembly of Membrane Proteins in Native Membranes studied by AFM
ID: 310080
Start date: 2013-01-01, End date: 2017-12-31
One of the key characteristics of life is the existence of boundaries that delineate the organism from its environment. The boundary membrane structure that defines all cells is called the plasma membrane. Membranes are constituted of a large variety of lipids and membrane pr...
Programme: FP7-IDEAS-ERC
Record Number: 105216
Last updated on: 2017-12-04
Regulation of Chromatin by Combinatorial DNA and Histone Modifications
ID: 309952
Start date: 2013-05-01, End date: 2019-04-30
The normal expression of genes is tightly regulated. Modifications on histones or on DNA play a central role in the control of gene expression and errors in their regulation often result in diseases such as cancer. These modifications can recruit proteins that regulate chroma...
Programme: FP7-IDEAS-ERC
Record Number: 107360
Last updated on: 2017-11-20
Dynamic sensory-motor integration  in spinal circuits
ID: 311673
Start date: 2013-02-01, End date: 2018-01-31
Although locomotion may seem effortless, it relies on spinal circuits producing extraordinarily complex patterns of muscle contractions. Graded movements occur over a wide range of amplitudes and frequencies, instantaneously adapting to changes in the environmental or inner s...
Programme: FP7-IDEAS-ERC
Record Number: 106880
Last updated on: 2017-11-20
Definition and characterization of type I interferonopathies
ID: 309449
Start date: 2013-03-01, End date: 2018-10-31
Although the concept of grouping Mendelian disorders associated with an up-regulation of type I interferon (IFN) has not been previously recognised in the medical literature, my past and current work argues that this concept has scientific validity and clinical utility. I bel...
Programme: FP7-IDEAS-ERC
Record Number: 107398
Last updated on: 2017-11-20
Molecular determinants of aphid host range
ID: 310190
Start date: 2013-02-01, End date: 2018-10-31
Many aphid species are restricted to one or few host plants, while some aphids, many of which are of agricultural importance, can infest a wide range of plant species. An important observation is that aphids spend a considerable time on nonhost species, where they probe the l...
Programme: FP7-IDEAS-ERC
Record Number: 105786
Last updated on: 2017-11-20
Nutrient sensing by parasites
[PROJECT] PARASITENUTRISENSING - Nutrient sensing by parasites
ID: 311502
Start date: 2012-12-01, End date: 2017-11-30
As any other obligate parasite, Plasmodium depends on its hosts and on the nutrients they provide to survive and complete its life cycle. Surprisingly, nothing is know about Plasmodium’s capacity to sense nutrients or its host’s nutritional status and thereby reprogram its me...
Programme: FP7-IDEAS-ERC
Record Number: 106248
Last updated on: 2017-11-20
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List retrieved on: 2018-06-18
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