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Anatomical and Functional Dissection of Neural Circuits in the Zebrafish Optic Tectum
ID: 311159
Start date: 2013-01-01, End date: 2018-06-30
The optic tectum has emerged as a tractable visuomotor transformer, in which anatomical and functional studies can allow a better understanding of how behavior is controlled by neuronal circuits. We plan to examine the formation and function of the visual system in zebrafish ...
Programme: FP7-IDEAS-ERC
Record Number: 106304
Last updated on: 2017-09-24
Molecular Mechanisms of GABAergic synapse formation: spatial segregation in cortical inhibitory inputs
ID: 310021
Start date: 2013-01-01, End date: 2018-06-30
Neuronal circuitries underlying the function of the mammalian cerebral cortex collectively constitute one of the most complex biological systems. As such, unraveling the mechanisms that control their development represents one of the most challenging questions in Science. Und...
Programme: FP7-IDEAS-ERC
Record Number: 105616
Last updated on: 2017-09-24
Endosomal dependent transport to the unique secretory organelles of apicomplexan parasites
ID: 309255
Start date: 2013-02-01, End date: 2019-01-31
Apicomplexan parasites invade the host cell in an active process that involves gliding motility, formation and movement through the moving junction (MJ) and establishment of a prasitophorous vacuole (PV) around the parasite. In order to invade the host cell they employ an ars...
Programme: FP7-IDEAS-ERC
Record Number: 105401
Last updated on: 2017-09-10
Mechanisms Underlying Treatment Responses in Psychosis
ID: 311686
Start date: 2013-03-01, End date: 2018-11-30
Psychotic symptoms (hallucinations and delusions) have been associated with a striatal hyperdopaminergic state. Less explored, but also implicated are functional abnormalities in cognitive control, particularly in the prefrontal cortex; and a functional and structural disconn...
Programme: FP7-IDEAS-ERC
Record Number: 106740
Last updated on: 2017-09-03
Therapies for inborn errors of metabolism
ID: 311596
Start date: 2012-11-01, End date: 2018-10-31
We discovered that phenylbutyrate, prevents both in vitro and in vivo the inactivation by phosphorylation of the branched chain ketoacid dehydrogenase complex (BCKDC) and pyruvate dehydrogenase complex (PDHC). We show that phenylbutyrate is effective for treatment of maple sy...
Programme: FP7-IDEAS-ERC
Record Number: 105793
Last updated on: 2017-09-03
NutrImmune: Nutrient-controlled molecular pathways instructing development and function of mucosa-associated innate lymphocytes
ID: 311377
Start date: 2013-03-01, End date: 2018-02-28
The last decade has witnessed an explosion of research into the molecular networks ensuring maintenance of a mutualistic relationship between microbes and host cell networks at mucosal surfaces. Failure of such homeostatic or adaptive programs lead to susceptibility to intest...
Programme: FP7-IDEAS-ERC
Record Number: 107185
Last updated on: 2017-09-03
Circuit mechanics of emotions in the limbic system
ID: 311701
Start date: 2013-01-01, End date: 2018-06-30
Numerous studies established the role of the limbic system in fear and reward: it integrates sensory information, encodes emotional states and instructs other brain centers to regulate physiology and behavior. The limbic system, however, consists of many distinct and highly i...
Programme: FP7-IDEAS-ERC
Record Number: 105747
Last updated on: 2017-08-27
Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers
ID: 310917
Start date: 2013-02-01, End date: 2019-01-31
Lymphoid cancers are among the most common human malignancies and characteristically harbour genomic aberrations. Although databases will soon be flooded with genome sequences from thousands of tumours, interpretation and validation of these data is limited by the genetic var...
Programme: FP7-IDEAS-ERC
Record Number: 106163
Last updated on: 2017-08-27
Dissecting the genetic basis of divergent and convergent evolution: From individuals to species radiations
ID: 310482
Start date: 2013-02-01, End date: 2019-01-31
Advances in genomics offer new opportunities for identifying loci that behave unusually against a background of neutral variation. Detecting divergent sites among related individuals and taxa can shed light on the process of adaptive divergence, from non-random mating to the ...
Programme: FP7-IDEAS-ERC
Record Number: 106425
Last updated on: 2017-08-27
Dosage sensitive genes in evolution and disease
ID: 309834
Start date: 2013-01-01, End date: 2018-12-31
Evolutionary change of gene copy number through gene duplication is a relatively pervasive phenomenon in eukaryotic genomes. However, for a subset of genes such changes are deleterious because they result in imbalances in the cell. Such dosage-sensitive genes have been increa...
Programme: FP7-IDEAS-ERC
Record Number: 104726
Last updated on: 2017-08-27
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List retrieved on: 2018-04-25
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