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Coevolution of bacteria and conjugative plasmids
ID: 311490
Start date: 2013-02-01, End date: 2018-01-31
Horizontal gene transfer (HGT) is a fundamental process of bacterial evolution, accelerating adaptation to novel environments and providing access to new ecological niches. However, two of the three mechanisms of HGT, transduction and conjugation, both rely on semi-autonomous...
Programme: FP7-IDEAS-ERC
Record Number: 105951
Last updated on: 2017-05-22
Genetic and Epigenetic Determinants of Paget's Disease of bone
ID: 311723
Start date: 2012-10-01, End date: 2018-03-31
Paget’s disease of bone (PDB) is a common disease characterised by focal areas of increased bone turnover leading to symptoms of bone pain, deformity, osteoarthritis and other complications. Genetic factors play an important role in PDB and mutations in SQSTM1 gene are respon...
Programme: FP7-IDEAS-ERC
Record Number: 105219
Last updated on: 2017-05-22
New biomarkers for Alzheimer’s & Parkinson’s diseases - key tools for early diagnosis and drug development
ID: 311292
Start date: 2013-06-01, End date: 2018-05-31
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are common in elderly and the prevalence of these is increasing. AD and PD have distinct pathogenesis, which precede the overt clinical symptoms by 10-15 years, opening a window for early diagnosis and treatment. New disea...
Programme: FP7-IDEAS-ERC
Record Number: 107847
Last updated on: 2017-05-22
In vivo pathogen proteome profiling using selected reaction monitoring
ID: 309831
Start date: 2013-05-01, End date: 2018-04-30
Bacterial infections represent a major and global health problem, which is further aggravated by the rapid and ongoing increase in antibiotic resistance. The limited success in the development of targeted therapies for particular invasive strains can be attributed to our limi...
Programme: FP7-IDEAS-ERC
Record Number: 107911
Last updated on: 2017-05-22
IN VIVO REPROGRAMMING: A NOVEL ROUTE TO BRAIN REPAIR
ID: 309712
Start date: 2013-03-01, End date: 2018-02-28
Recent progress on direct re-programming into functional neurons provides a new approach towards cell-based therapy for neurodegenerative disorders. The induced neurons (iNs) are a novel type of cell resulting from rapid and remarkable conversion of somatic cells into subtype...
Programme: FP7-IDEAS-ERC
Record Number: 107399
Last updated on: 2017-05-22
Exploring the tumor as a communicating organ
ID: 309322
Start date: 2013-03-01, End date: 2018-02-28
The failure to bring about major advances in cancer care over the past decades points to the need for a revolution in our view of cancer as a disease caused by a lack of growth control in malignant cells. We propose that a tumor should be considered a communicating organ made...
Programme: FP7-IDEAS-ERC
Record Number: 107397
Last updated on: 2017-05-22
Mechanistic dissection of myofibrillogenesis and sarcomerogenesis in insect muscle
ID: 310939
Start date: 2013-02-01, End date: 2019-01-31
Higher animals employ a complex muscle network for their daily movements. Proper execution of movements requires individual muscles to form at the correct positions, connect to proper tendons and produce sufficient force. Muscle development is a multi-step process: myoblasts ...
Programme: FP7-IDEAS-ERC
Record Number: 105666
Last updated on: 2017-05-08
analysis of postmitotic chromatin decondensation
ID: 309528
Start date: 2013-03-01, End date: 2018-02-28
Chromatin undergoes fascinating structural and functional changes during the metazoan cell cycle. It massively condenses at the beginning of mitosis with a degree of compaction up to fiftyfold higher than in interphase. At the end of mitosis, mitotic chromosomes decondense to...
Programme: FP7-IDEAS-ERC
Record Number: 106861
Last updated on: 2017-05-08
Closing in on missing heritability and immune dysregulation in macular degeneration
ID: 310644
Start date: 2013-01-01, End date: 2017-12-31
Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in the Western world. AMD has a strong genetic component, and it has been estimated that 50% of the heritability of AMD is explained by common variants in the complement system. Currentl...
Programme: FP7-IDEAS-ERC
Record Number: 106206
Last updated on: 2017-05-08
The interaction landscape between microbial colonization and functional genome of the host: a systems biology approach in fungal infections
ID: 310372
Start date: 2013-01-01, End date: 2017-12-31
Fungi such as Candida albicans are ubiquitous colonizers of human skin and mucosa. Fungal pathogens invade the host when host defence is diminished, and the combination of fungal and bacterial colonization modulates mucosal and systemic immune responses. Little is known of th...
Programme: FP7-IDEAS-ERC
Record Number: 105950
Last updated on: 2017-05-08
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List retrieved on: 2018-06-22
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