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Analysis of the interplay between genetic mutation and altered cellular metabolism in renal neoplasia
ID: 310837
Start date: 2013-01-01, End date: 2017-12-31
Defining and characterising the defective genes in hereditary cancer syndromes has advanced our understanding of cellular function and disease mechanisms. Interestingly, some of these genes have been directly implicated in metabolic dysregulation, thus providing a link betwee...
Programme: FP7-IDEAS-ERC
Record Number: 106738
Last updated on: 2016-12-05
Control mechanisms that pattern microtubules for switching cell division planes during plant morphogenesis
ID: 310068
Start date: 2013-01-01, End date: 2017-12-31
Oriented cell divisions dictate morphogenesis by shaping tissues and organs of multicellular organisms. Oriented cell divisions have profound influence in plants because their cell positions are locked by shared cell walls. A relay of cell divisions involving precise division...
Programme: FP7-IDEAS-ERC
Record Number: 106737
Last updated on: 2016-12-05
Irisin - a novel myokine protective against metabolic disease
ID: 309596
Start date: 2013-01-01, End date: 2017-12-31
Cardiovascular disease and diabetes constitute the major disease burden in the western world with growing morbidity. Exercise is known to ameliorate many of the key processes in the pathogenesis of these diseases, but the underlying mechanism is not clear. Especially little i...
Programme: FP7-IDEAS-ERC
Record Number: 105745
Last updated on: 2016-12-05
Elucidating early pathogenic mechanisms of neurodegeneration in Parkinson's disease through a humanized dynamic in vitro model
ID: 311736
Start date: 2013-07-01, End date: 2018-06-30
Our understanding of Parkinson’s disease (PD) pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic, most frequent, form of PD. It may be possible to overcome these challenges by reprogramming somatic...
Programme: FP7-IDEAS-ERC
Record Number: 108993
Last updated on: 2016-11-28
Non-coding RNA pathways and the mammalian male germline
ID: 310206
Start date: 2013-01-01, End date: 2017-12-31
The integrity of the genome transmitted to the next generation intrinsically relies on germline cells. Processes ensuring germ cell development, genomic stability and reproductive lifespan are essential for the long-term success of a species. Spermatogonial stem cells (SSCs) ...
Programme: FP7-IDEAS-ERC
Record Number: 105480
Last updated on: 2016-11-28
Cell migration in gut homeostasis and cancer invasion - role of microenvironment
ID: 311263
Start date: 2013-01-01, End date: 2017-12-31
The entire intestinal epithelium is renewed every week due to cell division in the crypts coupled with cell migration towards the villi and loss of cells by apoptosis at the tip of villi. Uncoupling cell proliferation from apoptosis and possibly from cell migration can lead t...
Programme: FP7-IDEAS-ERC
Record Number: 106354
Last updated on: 2016-11-23
Blood vessels as a target for infection
ID: 310790
Start date: 2013-01-01, End date: 2018-12-31
One of the major challenges in bacterial infectious disease relates to infections taking place in the bloodstream (septicemia). Despite availability of antibiotics these types of infections lead to extremely severe conditions such as septic shock or meningitis requiring a bet...
Programme: FP7-IDEAS-ERC
Record Number: 106020
Last updated on: 2016-11-23
Innate sensing of HIV and immune responses
ID: 309848
Start date: 2013-01-01, End date: 2017-12-31
Since its isolation in 1983 as a causative agent of AIDS, HIV-1 has remained an exceptional challenge. The human immune system usually ultimately fails at controlling infection by the virus. In contrast, most individuals infected with the related and poorly studied lentivirus...
Programme: FP7-IDEAS-ERC
Record Number: 106324
Last updated on: 2016-11-23
The quantitative Bcl-2 interactome in apoptosis: decoding how cancer cells escape death
ID: 309966
Start date: 2013-04-01, End date: 2019-03-31
The proteins of the Bcl-2 family function as key regulators of apoptosis by controlling the permeabilization of the mitochondrial outer membrane. They form an intricate, fine-tuned interaction network which is altered in cancer cells to avoid cell death. Currently, we do not ...
Programme: FP7-IDEAS-ERC
Record Number: 107660
Last updated on: 2016-10-31
Mechanisms of homeostatic plasticity in the intact mouse visual cortex
ID: 311695
Start date: 2013-01-01, End date: 2018-12-31
Changes in input lead to changes of synaptic circuits in the brain via a combination of synapse specific Hebbian plasticity and cell-wide homeostatic plasticity. While Hebbian plasticity has been well studied, there are still a number of outstanding fundamental questions rela...
Programme: FP7-IDEAS-ERC
Record Number: 105719
Last updated on: 2016-10-24
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List retrieved on: 2018-02-19
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