Community Research and Development Information Service - CORDIS

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Describing Evolution with Theoretical, Empirical, and Computational Tools
ID: 308796
Start date: 2013-01-01, End date: 2017-08-31
As evolutionary biologists we are of course motivated by the desire to gain further insight in to the evolution of natural populations. The main goals of this proposal are to (i) develop theory and methodology that will enable the identification of adaptively evolving genomic...
Programme: FP7-IDEAS-ERC
Record Number: 105328
Last updated on: 2016-10-17
A novel two-step model for neurodegeneration in Parkinson’s disease
ID: 311194
Start date: 2013-06-01, End date: 2018-05-31
Parkinson’s disease (PD) is the second most common neurodegenerative disorder primarily caused by the progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN). Despite the advances in gene discovery associated with PD, the knowledge of the PD pathogenesis is...
Programme: FP7-IDEAS-ERC
Record Number: 105788
Last updated on: 2016-10-03
Actin as the Master Organizer of Nuclear Structure and Function
ID: 310930
Start date: 2012-11-01, End date: 2018-08-31
Unlike previously thought the nucleus is a highly compartmentalized organelle. Both the genome and processes associated with it show non-random distribution within the nucleus. This compartmentalization has a fundamental impact on nuclear processes. However, the mechanisms dr...
Programme: FP7-IDEAS-ERC
Record Number: 105716
Last updated on: 2016-09-19
Spatial Integration in Cell Cytoskeleton
ID: 310472
Start date: 2012-12-01, End date: 2018-09-30
The functional coherence in multicellular arrangements depends on each cell’s ability to adapt its internal organisation to the spatial configuration of their microenvironment. The asymmetric distributions of cell compartments and peripheral domains define the cell polarity. ...
Programme: FP7-IDEAS-ERC
Record Number: 105905
Last updated on: 2016-09-19
DNA binding proteins for treatment of gain of function mutations
ID: 311682
Start date: 2013-02-01, End date: 2018-01-31
Zinc finger (ZF) and transcription activator-like effector (TALE) based technologies are been allowing the tailored design of “artificial” DNA-binding proteins targeted to specific and unique DNA genomic sequences. Coupling DNA binding proteins to effectors domains enables th...
Programme: FP7-IDEAS-ERC
Record Number: 106921
Last updated on: 2016-09-12
Exploring the human brain using magnetic resonance imaging and parallel transmission at ultra-high field
ID: 309674
Start date: 2013-02-01, End date: 2019-01-31
Full exploitation of ultra high field magnetic resonance imaging (MRI) requires innovative methods to control the homogeneity and the safety of the high frequency radiofrequency (RF) waves used to acquire images. This can be achieved by using parallel transmission of the RF w...
Programme: FP7-IDEAS-ERC
Record Number: 106879
Last updated on: 2016-09-05
Complex Synthetic Mimics of the Cell Membrane
ID: 309651
Start date: 2013-02-01, End date: 2018-10-31
I propose to bridge the gap between simple in vitro measurements of biological processes, and the complexities of the cellular environment. This requires reduced in vitro systems that are sufficiently complex to reproduce the subtleties of the in vivo biological phenomenon, b...
Programme: FP7-IDEAS-ERC
Record Number: 106913
Last updated on: 2016-09-05
Order in Disorder: Context-dependent strategies for integrating peptide-mediated interactions
ID: 310873
Start date: 2012-12-01, End date: 2017-11-30
Peptide-mediated protein interactions are emerging as key regulators of many important regulatory processes in the cell. Short motifs, usually embedded into disordered regions of the protein, interact with specific sets of protein partners in a transient way and allow efficie...
Programme: FP7-IDEAS-ERC
Record Number: 105647
Last updated on: 2016-08-29
‘Seeing’ with the ears, hands and bionic eyes: from theories about brain organization to visual rehabilitation
ID: 310809
Start date: 2013-09-01, End date: 2018-08-31
My lab's work ranges from basic science, querying brain plasticity and sensory integration, to technological developments, allowing the blind to be more independent and even “see” using sounds and touch similar to bats and dolphins (a.k.a. Sensory Substitution Devices, SSDs),...
Programme: FP7-IDEAS-ERC
Record Number: 109040
Last updated on: 2016-08-29
Environmentally-induced Developmental Origins of Health and Disease
ID: 311765
Start date: 2013-02-01, End date: 2018-01-31
The DOHaD (Developmental Origins of Health and Disease) hypothesis states that, because of developmental plasticity, in utero and early postnatal stressors can increase chronic disease risk in childhood and later. Alterations of epigenetic marks, impacting on gene expression,...
Programme: FP7-IDEAS-ERC
Record Number: 106798
Last updated on: 2016-08-19
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List retrieved on: 2018-07-23
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