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Hypothalamic Lipotoxicity and Endoplasmic Reticulum Stress: a New Pathophysiological Mechanism of Obesity
ID: 281854
Start date: 2011-12-01, End date: 2017-05-31
It is well established that metabolically relevant organs such as adipose tissue, pancreatic beta cells, liver and skeletal muscle develop endoplasmic reticulum (ER) stress under conditions of obesity induced lipotoxicity. Here, the applicant will investigate if/how the hypot...
Programme: FP7-IDEAS-ERC
Record Number: 100682
Last updated on: 2018-01-22
Science and technology development for in situ detection and cjharacterization of subsurface life on the Iberian Pyritic Belt
ID: 250350
Start date: 2010-06-01, End date: 2015-05-31
Terrestrial subsurface geomicrobiology is a matter of growing interest on many level. From a fundamental point of view, it seeks to determine wheter life can be sustained in the absence of radiation. From an astrobiological point of view, it is an interesting model for early ...
Programme: FP7-IDEAS-ERC
Record Number: 94586
Last updated on: 2018-01-22
Conversion, Overlapping Religiosities, Polemics, Interaction: Early Modern Iberia and Beyond
ID: 323316
Start date: 2013-04-01, End date: 2019-03-31
In an early sixteenth-century treatise Martín de Figuerola, a convert from Islam who sought to convince the Muslims of Valencia and Aragon to join him, reports a story he claims to have heard from the Muslim judge of Cocentaina (Valencia). The latter had told him that, in mar...
Programme: FP7-IDEAS-ERC
Record Number: 108102
Last updated on: 2018-01-08
Gas and Dust from the Stars to the Laboratory: Exploring the NanoCosmos
ID: 610256
Start date: 2014-08-01, End date: 2020-07-31
Evolved stars are the factories of interstellar dust. This dust is injected into the interstellar medium and plays a key role in the evolution of astronomical objects from galaxies to the embryos of planets. However, the processes involved in dust formation and evolution are ...
Programme: FP7-IDEAS-ERC
Record Number: 191294
Last updated on: 2018-01-03
Effects of phosphorus limitations on Life, Earth system and Society
ID: 610028
Start date: 2014-09-01, End date: 2020-08-31
P is an earthbound and finite element and the prospect of constrained access to mineable P resources has already triggered geopolitical disputes. In contrast to P, availabilities of carbon (C) and nitrogen (N) to ecosystems are rapidly increasing in most areas of the globe. T...
Programme: FP7-IDEAS-ERC
Record Number: 191353
Last updated on: 2018-01-03
Dynamics of human genome architecture in stable and transient gene expression changes
ID: 609989
Start date: 2014-06-01, End date: 2019-05-31
The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the...
Programme: FP7-IDEAS-ERC
Record Number: 191292
Last updated on: 2018-01-03
Bi-literacy: Learning to read in L1 and in L2
ID: 295362
Start date: 2012-05-01, End date: 2017-04-30
Learning to read is probably one of the most exciting discoveries in our life. Using a longitudinal approach, the research proposed examines how the human brain responds to two major challenges: (a) the instantiation a complex cognitive function for which there is no genetic ...
Programme: FP7-IDEAS-ERC
Record Number: 103543
Last updated on: 2018-01-03
p53 as a New Mediator of Energy Balance in the Brain
ID: 281408
Start date: 2011-12-01, End date: 2017-05-31
p53 is a transcriptional factor modulating numerous biological actions. Although it is best known for its role in cancer development, it is now evident that it is implicated in metabolism. More specifically, p53 modulates energy metabolism and homeostasis through their effect...
Programme: FP7-IDEAS-ERC
Record Number: 100931
Last updated on: 2018-01-03
Systematic investigation of epistasis in molecular evolution
ID: 335980
Start date: 2014-01-01, End date: 2018-12-31
Why does a mutation have a deleterious effect when it occurs in one species but shows no apparent consequences on the phenotype when it occurs in another species? What are some of possible explanations on the molecular basis of this phenomenon? Are the computational predictio...
Programme: FP7-IDEAS-ERC
Record Number: 111571
Last updated on: 2017-12-18
Wiring up visual circuits: Interplay between gene expression and spontaneous and experience-dependent activity
ID: 282329
Start date: 2012-01-01, End date: 2017-06-30
A fundamental feature of the developing neural circuits is their ability to change in response to sensorial experience. This phenomenon has been particularly observed during the generation of cortical maps, where altering the pattern of sensory experience changes the spatial ...
Programme: FP7-IDEAS-ERC
Record Number: 101546
Last updated on: 2017-12-18
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List retrieved on: 2018-04-23
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