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FP7-IDEAS-ERC (1559)


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Results 1 - 10 of 1559
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Factor XII and the contact system: 
cross-talk between thrombosis and inflammation
ID: 311575
Start date: 2013-08-01, End date: 2018-07-31
Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. This system starts a cascade of proc...
Programme: FP7-IDEAS-ERC
Record Number: 109422
Last updated on: 2018-01-22
Next generation sequencing for detection of human primary immunodeficiency syndromes characterized by impaired cytotoxic lymphocyte function
ID: 311335
Start date: 2013-05-01, End date: 2018-04-30
Human primary immunodeficiencies affecting cytotoxic lymphocyte function are associated with high morbidity and mortality. They often present as hyperinflammatory syndromes triggered by viral infections, hematological malignancies, or systemic autoimmunity. Although recent ad...
Programme: FP7-IDEAS-ERC
Record Number: 108234
Last updated on: 2018-01-22
Regulation of gene expression and cell fate by DNA (hydroxy)methylation
ID: 309384
Start date: 2013-10-01, End date: 2018-09-30
(Hydroxy)methylation of cytosine residues in eukaryotic DNA represents a major means to regulate gene expression during development. These modifications are considered to be epigenetic marks, since they have a profound impact on phenotype, but are inherited from mother to dau...
Programme: FP7-IDEAS-ERC
Record Number: 105899
Last updated on: 2018-01-22
Hypothalamic Lipotoxicity and Endoplasmic Reticulum Stress: a New Pathophysiological Mechanism of Obesity
ID: 281854
Start date: 2011-12-01, End date: 2017-05-31
It is well established that metabolically relevant organs such as adipose tissue, pancreatic beta cells, liver and skeletal muscle develop endoplasmic reticulum (ER) stress under conditions of obesity induced lipotoxicity. Here, the applicant will investigate if/how the hypot...
Programme: FP7-IDEAS-ERC
Record Number: 100682
Last updated on: 2018-01-22
Mechanisms of cell fusion in eukaryotes
[PROJECT] ELEGANSFUSION - Mechanisms of cell fusion in eukaryotes
ID: 268843
Start date: 2011-05-01, End date: 2016-04-30
Membrane fusion is a universal process essential inside cells (endoplasmic) and between cells in fertilization and organ formation (exoplasmic). With the exception of SNARE-mediated endoplasmic fusion the proteins that mediate cellular fusion (fusogens) are unknown. Despite m...
Programme: FP7-IDEAS-ERC
Record Number: 98859
Last updated on: 2018-01-22
Genome Stability Mechanisms in Aging
ID: 260383
Start date: 2011-07-01, End date: 2017-02-28
Genome Instability has been recognized as causal factor of cancer and recently also as a major contributing factor of aging. A number of progeroid (premature aging-like) syndromes are linked to defects in nucleotide excision repair (NER). NER thus provides a highly relevant e...
Programme: FP7-IDEAS-ERC
Record Number: 97804
Last updated on: 2018-01-22
Science and technology development for in situ detection and cjharacterization of subsurface life on the Iberian Pyritic Belt
ID: 250350
Start date: 2010-06-01, End date: 2015-05-31
Terrestrial subsurface geomicrobiology is a matter of growing interest on many level. From a fundamental point of view, it seeks to determine wheter life can be sustained in the absence of radiation. From an astrobiological point of view, it is an interesting model for early ...
Programme: FP7-IDEAS-ERC
Record Number: 94586
Last updated on: 2018-01-22
The role of parvalbumin interneurons in cognition and behavior
ID: 337069
Start date: 2014-02-01, End date: 2019-01-31
Cognition is a collective term for complex but sophisticated mental processes such as attention, learning, social interaction, language production, decision making and other executive functions. For normal brain function, these higher-order functions need to be aptly regulate...
Programme: FP7-IDEAS-ERC
Record Number: 191310
Last updated on: 2018-01-15
Disarming bacterial weapons in the nucleus:
functional study of Chlamydia nuclear effectors
ID: 282046
Start date: 2012-07-01, End date: 2018-06-30
The high prevalence of Chlamydia infections and the heavy burden they inflict on public health justify the search for novel therapeutic approaches directed against this pathogen. Research on this obligate intracellular bacterium is very difficult, due to substantial technical...
Programme: FP7-IDEAS-ERC
Record Number: 103960
Last updated on: 2018-01-15
Ploidy change as a rapid mechanism of adaptation
ID: 340087
Start date: 2014-01-01, End date: 2019-12-31
Fungi are particularly challenging pathogens; because they and their human hosts are eukaryotes. We will study how new traits such as drugR arise rapidly using Candida albicans, the most prevalent fungal pathogen of humans. The work explores the ground-breaking concept that a...
Programme: FP7-IDEAS-ERC
Record Number: 111319
Last updated on: 2018-01-08
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List retrieved on: 2018-03-21
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