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Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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Mechanisms of cell fusion in eukaryotes
[PROJECT] ELEGANSFUSION - Mechanisms of cell fusion in eukaryotes
ID: 268843
Start date: 2011-05-01, End date: 2016-04-30
Membrane fusion is a universal process essential inside cells (endoplasmic) and between cells in fertilization and organ formation (exoplasmic). With the exception of SNARE-mediated endoplasmic fusion the proteins that mediate cellular fusion (fusogens) are unknown. Despite m...
Programme: FP7-IDEAS-ERC
Record Number: 98859
Last updated on: 2018-01-22
COELIAC DISEASE: UNDERSTANDING HOW A FOREIGN PROTEIN DRIVES AUTOANTIBODY FORMATION
ID: 268541
Start date: 2011-05-01, End date: 2017-04-30
The goal of this project is to understand the mechanism of how highly disease specific autoantibodies are generated in response to the exposure to a foreign antigen. IgA autoantibodies reactive with the enzyme transglutaminase 2 (TG2) are typical of coeliac disease (CD). Thes...
Programme: FP7-IDEAS-ERC
Record Number: 98703
Last updated on: 2018-01-03
General and targeted approaches to unravel the molecular causes of type 2 diabetes
ID: 269045
Start date: 2011-05-01, End date: 2016-04-30
Type 2 diabetes (T2D) affects worldwide at present about 250 million patients and an estimated 380 million in 2025. This epidemic has been ascribed to a collision between genes and an affluent society. Genetics of T2D has during recent years identified > 30 variants increasin...
Programme: FP7-IDEAS-ERC
Record Number: 98878
Last updated on: 2017-12-04
Exploiting plants for the production of future generation recombinant pharmaceuticals
ID: 269110
Start date: 2011-08-01, End date: 2019-01-31
Biopharmaceutical proteins are typically produced in cultivated mammalian cells, a costly process with limited scalability. Thus products such as monoclonal antibodies are very expensive and often beyond the reach of the world’s poor. The problem is compounded by the fact tha...
Programme: FP7-IDEAS-ERC
Record Number: 99830
Last updated on: 2017-11-20
Lymphocyte microRNAs in health and disease: Understanding lymphocyte functions through the identification of microRNA target genes and exploiting serum microRNA signatures to monitor immune responses
ID: 269022
Start date: 2011-06-01, End date: 2016-05-31
Background: CD4+ T lymphocyte subsets orchestrate immune responses in health and disease. Little is known on control of T cell differentiation exerted by microRNA that affect mRNA translation. The identification of microRNA and their targets that regulate differentiation of T...
Programme: FP7-IDEAS-ERC
Record Number: 99074
Last updated on: 2017-11-20
Eukaryotic genomic origins, parasites, and the essential nature of mitochondria
ID: 268701
Start date: 2011-03-01, End date: 2017-02-28
Understanding the origin and evolution of eukaryotes, their genomes and organelles, are among the most important and exciting challenges facing biology. However, determining ancient gene origins tests methods and data to their limits, and it is unrealistic to expect progress ...
Programme: FP7-IDEAS-ERC
Record Number: 98151
Last updated on: 2017-11-20
Disseminating tumor cells as novel biomarkers: Dissecting the metastatic cascade in cancer patients
ID: 269081
Start date: 2011-08-01, End date: 2016-07-31
Breast, prostate, lung and colorectal cancer as solid tumours derived from epithelial tissues are responsible for 90% of all new cancers in Europe. Present tumour staging is mainly based on local tumour extension, metastatic lymph node involvement and evidence of overt distan...
Programme: FP7-IDEAS-ERC
Record Number: 99776
Last updated on: 2017-11-20
Mapping the life histories of T cells
[PROJECT] LIFE-HIS-T - Mapping the life histories of T cells
ID: 268733
Start date: 2011-05-01, End date: 2017-01-31
T cells display many different phenotypes and functions, depending on the nature of previously encountered signals. If we want to understand how these different T cell subsets arise, we need to be able to follow individual T cells and their progeny through time. With the aim ...
Programme: FP7-IDEAS-ERC
Record Number: 98547
Last updated on: 2017-10-06
The Immune function of NK cells
ID: 268537
Start date: 2011-07-01, End date: 2016-12-31
In this project, we propose to explore a new area in biological research aiming at dissecting emerging of properties of the innate immune responses. Our system model is the Natural Killer (NK) cell. Specifically, we will investigate the mechanisms by which these players of in...
Programme: FP7-IDEAS-ERC
Record Number: 99481
Last updated on: 2017-10-06
Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
ID: 268548
Start date: 2011-06-01, End date: 2017-02-28
In the present proposal, we plan to examine the dendrites, axons, and presynaptic terminals of fast-spiking, parvalbumin-expressing GABAergic interneurons using subcellular patch-clamp methods pioneered by the PI, imaging techniques, and computational approaches. The goal is ...
Programme: FP7-IDEAS-ERC
Record Number: 98450
Last updated on: 2017-09-24
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List retrieved on: 2018-08-21
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