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Therapies for inborn errors of metabolism
ID: 311596
Data rozpoczęcia: 2012-11-01, Data zakończenia: 2018-10-31
We discovered that phenylbutyrate, prevents both in vitro and in vivo the inactivation by phosphorylation of the branched chain ketoacid dehydrogenase complex (BCKDC) and pyruvate dehydrogenase complex (PDHC). We show that phenylbutyrate is effective for treatment of maple sy...
Programme: FP7-IDEAS-ERC
Record Number: 105793
Last updated on: 2017-09-03
DNA binding proteins for treatment of gain of function mutations
ID: 311682
Data rozpoczęcia: 2013-02-01, Data zakończenia: 2018-01-31
Zinc finger (ZF) and transcription activator-like effector (TALE) based technologies are been allowing the tailored design of “artificial” DNA-binding proteins targeted to specific and unique DNA genomic sequences. Coupling DNA binding proteins to effectors domains enables th...
Programme: FP7-IDEAS-ERC
Record Number: 106921
Last updated on: 2016-09-12
Unravelling paradoxes in regulatory T cell biology: the molecular basis for an mTOR-dependent oscillatory metabolic switch controlling immune tolerance and autoimmunity
ID: 310496
Data rozpoczęcia: 2013-05-01, Data zakończenia: 2018-04-30
Our group has been investigating how the nutrient/energy-sensing mammalian target of rapamycin (mTOR)-pathway affects the responsiveness of CD4+CD25+FoxP3+ regulatory T cells (Tregs). We have shown that Tregs have a high metabolic profile associated with the hyperactivation o...
Programme: FP7-IDEAS-ERC
Record Number: 108004
Last updated on: 2016-03-31
Biotechnological optimization of light use efficiency in algae photobioreactors
ID: 309485
Data rozpoczęcia: 2012-10-01, Data zakończenia: 2017-09-30
New renewable energy source are highly needed to compensate exhausting fossil fuels reserves and reduce greenhouse gases emissions. Some species of algae have an interesting potential as feedstock for the production of biodiesel thanks to their ability to accumulate large amo...
Programme: FP7-IDEAS-ERC
Record Number: 105215
Last updated on: 2016-03-31
List retrieved on: 2018-09-19
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