Obiettivo
The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines.
ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recruited per year. This should lead to the constitution of the largest possible cohort in Europe for the study of immunogenicity, a condition critical for the success of the program. ABIRISK will also benefit from the unique expertise of immunologist partners in the development of innovative strategies for predicting the immunogenicity of biopharmaceuticals and for defining its mechanisms. The large number of patients enrolled in the ABIRISK cohorts should make it possible to study the genetic basis of immunogenicity in a new way.
We will standardize all clinical and biological information before its integration into a large database for evaluation of the clinical relevance of immunization against biopharmaceuticals and stratification of the risk to patients as a function of factors linked to treatment or to the individual. Computational biology and biostatistical modeling will be used to develop models for predicting immunogenicity that will be validated with the ABIRISK database.
The complementarity between the clinical partners from different disciplines, immunologists, methodologists and biostatisticians will create a unique task force for studies of biopharmaceutical immunogenicity. The direct outcomes of the proposed work will be greater understanding of the mechanisms involved in the emergence of anti-drug antibodies, the development of new methods for predicting immunogenicity and a comprehensive view of the respective value of predictive tools, and guidelines for the development of new biopharmaceuticals and patient care.
Campo scientifico
- medical and health sciencesclinical medicinerheumatology
- natural sciencescomputer and information sciencesdatabases
- medical and health sciencesbasic medicineimmunologyimmunisation
- medical and health sciencesbasic medicineneurologymultiple sclerosis
- medical and health sciencesclinical medicinegastroenterology
Invito a presentare proposte
IMI-JU-03-2010
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Meccanismo di finanziamento
JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)Coordinatore
4056 Basel
Svizzera
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Partecipanti (37)
75654 Paris
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50121 Florence
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6500 Bellinzona
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75015 PARIS 15
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DK-2100 Copenhagen
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WC1E 6BT London
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2333 ZA Leiden
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1105AZ Amsterdam
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16147 Genova
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75010 Paris
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31096 Haifa
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53127 Bonn
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63225 Langen
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60323 Frankfurt Am Main
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17177 Stockholm
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6020 Innsbruck
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40225 Dusseldorf
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3400 Hillerod
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4031 Basel
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08035 Barcelona
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E1 4NS London
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81675 Muenchen
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75794 Paris
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53100 Siena
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68167 Mannheim
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116 36 Praha 1
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CT13 9NJ Sandwich
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TW89GS Brentford
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1070 Bruxelles / Brussel
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94250 GENTILLY
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64293 Darmstadt
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2880 Bagsvaerd
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13353 Berlin
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91940 Les Ulis
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52621 Ramat Gan
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54123 SKOVDE
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75012 Paris
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