Objectif This project will study 5 special populations throughout Europe which represent a unique resource for genomic research. It will quantify genetic variation in genes known to be involved in health and disease and will harness this variation to identify novel variants. The project will build on the achievements of substantial existing investment in these special populations and will pool expertise across Europe in phenotyping, genotyping, statistical genetics and social and ethical aspects of genomic research. A common database of health and disease-related phenotypes will be established and cores of expertise established in the major project areas.this will create the largest database of phenotypic and genotypic data from genetic isolate populations and thus will improve European competitiveness in gene discovery. The project will also provide the platform for the evaluation of a novel gene discovery approach (hybrid identity profiling) which has been developed by a European SME.Study objectives include:To describe the variation in allele frequencies in genetic variants involved in health or disease states;To harmonise existing health and disease-related phenotype data and reach agreement on genotyping procedures; To adopt standard definitions, measurement methods and common data storage formats to form a common study database. To evaluate a novel European technology developed by IntegraGen (SME) for discovery of novel genetic variants;To undertake an extended pedigree based genome-wide linkage analysis to identify quantitative trait loci (QTL) underlying a large number of traits which underlie many of the main diseases of public health importance in Europe. Cross population mapping methods will be employed in fine mapping;To develop new statistical methods for pedigree based linkage analysis in these special populations;To define a best approach for dealing with related ethical and social issues in these populations. Champ scientifique natural sciencesbiological sciencesgeneticsnatural sciencescomputer and information sciencessoftwaremedical and health scienceshealth sciencespublic healthnatural sciencescomputer and information sciencesdatabasessocial sciencessociologysocial issues Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Appel à propositions FP6-2004-LIFESCIHEALTH-5 Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur THE UNIVERSITY OF EDINBURGH Contribution de l’UE Aucune donnée Adresse Old College, South Bridge EDINBURGH Royaume-Uni Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire MEDICAL RESARCH COUNCIL Royaume-Uni Contribution de l’UE Aucune donnée Adresse 20 Park Crescent n/a LONDON Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée ERASMUS MEDICAL CENTER, ROTTERDAM Pays-Bas Contribution de l’UE Aucune donnée Adresse Dr Molewaterplein 50 1738 ROTTERDAM Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITY OF UPPSALA, Suède Contribution de l’UE Aucune donnée Adresse St Olobsgatan 10B 256 UPPSALA Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée GSF - FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT, GMBH Allemagne Contribution de l’UE Aucune donnée Adresse Ingolstaedter Landstr. 1 1129 MUNCHEN-NEUHERBERG Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée SVEUCILISTE U ZABREBU, MEDICINSKI FACULTET Croatie Contribution de l’UE Aucune donnée Adresse Salata 3/B n/a ZAGREB Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée INTEGRAGEN SA France Contribution de l’UE Aucune donnée Adresse 4, rue Pierre Fontaine EVRY Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée ACCADEMIA EUROPEA BOLZANO Italie Contribution de l’UE Aucune donnée Adresse Drususallee 1 n/a BOLZANO Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée