Objective The focus of 'EPISTEM' is to generate new knowledge and translate it into applications that enhance human health. To this end both fundamental and applied research will be involved. 'EPISTEM' integrates multidisciplinary and coordinated efforts to understand the molecular basis of factors involved in epidermal stem cell generation, maintenance and differentiation and skin disease. Moreover, the core molecule that will be studied in this IP is p63 (and related pathways), a molecule genetically proven to be involved in the development of rare skin diseases such as EEC syndrome, Hay-Wells (AEC) syndrome, Limb-mammary syndrome, ADULT syndrome, Rapp-Hodgkin syndrome and non-syndromic split hand-split foot malformation. Collectively, the prevalence of ectodermal dysplasia syndromes (EDS) is estimated at 7 cases in 10,000 births. Currently there is no cure for these patients. By creating the 'EPISTEM' consortium we want to address from different angles (genetics, gene profiling, molecular and cellular biology, structural biology, drug design, bioinformatics), the molecular pathways involved in epidermal dysplasia syndromes making use of different technologies (mutation analysis, micro-array, ChiP, transgenes, proteomics, in vitro skin cultures, crystallography, etc). Our consortium brings together leading European clinicians, geneticists, molecular and cellular biologists, structural biologists, a drug designer and bioinformatics specialist in the field of p63 (and related molecules) research. Therefore, this research fits in the centre of the specific topic "Exploring the potential of stem cells and/or primary cells for the understanding of monogenic rare diseases and the development of new drugs for their treatments". Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesbasic medicinemedicinal chemistrynatural sciencesearth and related environmental sciencesgeologymineralogycrystallographymedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencesbiological sciencesgeneticsmutation Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2004-1.2.1-3 - Exploring the potential of stem cells and/or primary cells, for the understanding of monogenic rare diseases and the development of new drugs for their treatment Call for proposal FP6-2004-LIFESCIHEALTH-5 See other projects for this call Funding Scheme IP - Integrated Project Coordinator FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW EU contribution No data Address Rijvisschestraat 120 GENT-ZWIJNAARDE Belgium See on map Links Website Opens in new window Total cost No data Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all RADBOUD UNIVERSITEIT NIJMEGEN Netherlands EU contribution No data Address Geert Grooteplein Zuid 10 NIJMEGEN See on map Links Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Italy EU contribution No data Address Via Orazio Raimondo 18 ROME See on map Links Website Opens in new window Total cost No data UNIVERSITY OF LAUSANNE Switzerland EU contribution No data Address Bâtiment du Rectorat et de l'Administration (BRA) LAUSANNE See on map Links Website Opens in new window Total cost No data KING'S COLLEGE LONDON United Kingdom EU contribution No data Address Strand LONDON See on map Links Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution No data Address Nobels väg 5 STOCKHOLM See on map Links Website Opens in new window Total cost No data INSTITUTO ONCOLOGICO DEL MEDITERRANEO SPA Italy EU contribution No data Address Via Penninazoo nr 7 VIAGRANDE (CT) See on map Links Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Rue de Tolbiac PARIS See on map Links Website Opens in new window Total cost No data GENESPIN SRL Italy EU contribution No data Address Via Celoria 26 MILANO See on map Links Website Opens in new window Total cost No data CHIANG MAI UNIVERSITY Thailand EU contribution No data Address 239, Huay Kaew Road CHIANG MAI See on map Links Website Opens in new window Total cost No data SHANGHAI JIAOTONG UNIVERSITY, SHANGHAI, P.R. CHINA China EU contribution No data Address 1954, Huashan Road SHANGHAI See on map Links Website Opens in new window Total cost No data J. W. GOETHE-UNIVERSITÄT FRANKFURT AM MAIN Germany EU contribution No data Address Senckenberganlage 31 FRANKFURT / MAIN See on map Links Website Opens in new window Total cost No data UNIVERSITÀ DEGLI STUDI DI MILANO Italy EU contribution No data Address Via Festa del Perdono 7 MILANO See on map Links Website Opens in new window Total cost No data