Objectif Standard therapy of infection with the human immunodeficiency virus type 1 (HIV-1) is based on potent cocktails of drugs targeting viral proteins. This treatment is associated with severe side effects and is almost unaffordable for the patients living in sub-Saharan Africa. Incomplete suppression of HIV replication results in drug-resistance. Therefore, a continued research effort is required to develop more potent, cheaper and less toxic antivirals. The insight has grown that HIV requires cellular proteins to serve as co-factors for viral replication. Our over-all objective is to develop novel drugs by targeting co-factors required for HIV replication. The virus will find it difficult to develop antiviral resistance against drugs targeting interaction between invariable cellular proteins and conserved viral protein domains. We will focus on the cellular proteins that mediate HIV trafficking, nuclear import and integration, such as Lens Epithelium Derived Growth Factor (LEDGF/p75), a novel cofactor of HIV-1 integration. THINC is composed of 3 virologists, 2 medicinal chemists, 1 virologist from South Africa, 1 structural biologist, 1 pharmaceutical company. Our first objective is to identify and validate novel co-factors of HIV trafficking, nuclear import and integration as novel targets for anti-HIV therapy. The second objective is to develop new drugs against the validated cellular target LEDGF/p75. The third objective is to perform this work in the perspective of those who will benefit most: the HIV infected people all over the world. The initial steps of target validation and hit identification will mainly be taken by academic groups, while optimization and (pre)clinical development of drugs requires the participation of Tibotec, a European company devoted to the development of antiviral drugs. The project will also increase our generic understanding of protein-protein interactions (PPI). Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistancemedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals Mots‑clés AIDS HIV LEDGF/p75 antiviral drugs co-factors import integration protein protein interaction resistance Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH-2007-2.3.2-1 - HIV/AIDS Drug Discovery and Preclinical Development Appel à propositions FP7-HEALTH-2007-A Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur KATHOLIEKE UNIVERSITEIT LEUVEN Contribution de l’UE € 894 733,72 Adresse OUDE MARKT 13 3000 Leuven Belgique Voir sur la carte Région Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Type d’activité Higher or Secondary Education Establishments Contact administratif Marleen Verlinden (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (10) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire SCUOLA NORMALE SUPERIORE Participation terminée Italie Contribution de l’UE € 228 549,95 Adresse PIAZZA DEI CAVALIERI 7 56126 Pisa Voir sur la carte Région Centro (IT) Toscana Pisa Type d’activité Higher or Secondary Education Establishments Contact administratif Beatrice Semzaconi (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI SIENA Italie Contribution de l’UE € 352 002,00 Adresse VIA BANCHI DI SOTTO 55 53100 Siena Voir sur la carte Région Centro (IT) Toscana Siena Type d’activité Higher or Secondary Education Establishments Contact administratif Massimo Ferri (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI MESSINA Italie Contribution de l’UE € 285 200,00 Adresse PIAZZA PUGLIATTI 1 98122 Messina Voir sur la carte Région Isole Sicilia Messina Type d’activité Higher or Secondary Education Establishments Contact administratif Maria Antonella Cocchiara (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée TIBOTECH PHARMACEUTICALS LTD Participation terminée Irlande Contribution de l’UE Aucune donnée Adresse East Gate Village - LITTLE ISLAND - CORK Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Leo Versteynen (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITY OF KWAZULU-NATAL Afrique du Sud Contribution de l’UE € 226 505,00 Adresse University Road, Chiltern Hills 3630 Westville Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Paulina Motshehoa Mokotedi (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. Tchéquie Contribution de l’UE € 227 600,00 Adresse FLEMINGOVO NAM. 542/2 16610 Praha 6 Voir sur la carte Région Česko Praha Hlavní město Praha Type d’activité Research Organisations Contact administratif Renata Sroglova (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITE DE GENEVE Suisse Contribution de l’UE € 404 600,00 Adresse RUE DU GENERAL DUFOUR 24 1211 Geneve Voir sur la carte Région Schweiz/Suisse/Svizzera Région lémanique Genève Type d’activité Higher or Secondary Education Establishments Contact administratif Alex Waehry (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI PERUGIA Italie Contribution de l’UE € 66 000,00 Adresse PIAZZA DELL UNIVERSITA 1 06123 Perugia Voir sur la carte Région Centro (IT) Umbria Perugia Type d’activité Higher or Secondary Education Establishments Contact administratif Francesco Bistoni (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée JANSSEN INFECTIOUS DISEASES DIAGNOSTICS BVBA Participation terminée Belgique Contribution de l’UE € 72 881,44 Adresse TURNHOUTSEWEG 30 2340 BEERSE Voir sur la carte Région Vlaams Gewest Prov. Antwerpen Arr. Turnhout Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Leo Versteynen (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI TRENTO Italie Contribution de l’UE € 181 599,89 Adresse VIA CALEPINA 14 38122 Trento Voir sur la carte Région Nord-Est Provincia Autonoma di Trento Trento Type d’activité Higher or Secondary Education Establishments Contact administratif Vanessa Ravagni (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée