Cel "The dynamic nature of the brain operates at disparate time scales ranging from milliseconds to months. How do single neurons change over such long time scales? This question remains stubborn to answer in the field of brain plasticity mainly because of limited tools to study the physiology of single neurons over time in the complex environment of the brain. The research aim of this proposal is to reveal the physiological changes of single neurons in the mammalian brain over disparate time scales using time-lapse optical imaging. Specifically, we aim to establish a new team that will develop genetic and optical tools to probe the physiological activity of single neurons, in vivo. As a model system, we will study a unique neuronal population in the mammalian brain; the adult-born local neurons in the olfactory bulb. These neurons have tremendous potential to reveal how neurons develop and maintain in the intact brain because they are accessible both genetically and optically. By following the behavior of adult-born neurons in vivo we will discover how neurons mature and maintain over days and weeks. If our objectives will be met, this study has the potential to significantly ""raise the bar"" on how neuronal plasticity is studied and reveal some basic secrets of the ever changing mammalian brain." Dziedzina nauki natural sciencesbiological sciencesneurobiologynatural sciencesbiological scienceszoologymammalogyengineering and technologymedical engineeringdiagnostic imaging Słowa kluczowe Plasticity olfaction Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-SG-LS4 - ERC Starting Grant - Physiology, Pathophysiology and Endocrinology Zaproszenie do składania wniosków ERC-2007-StG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-SG - ERC Starting Grant Instytucja przyjmująca THE HEBREW UNIVERSITY OF JERUSALEM Wkład UE € 1 750 000,00 Adres EDMOND J SAFRA CAMPUS GIVAT RAM 91904 Jerusalem Izrael Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Irit Harat (Ms.) Kierownik naukowy Adi Mizrahi (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko THE HEBREW UNIVERSITY OF JERUSALEM Izrael Wkład UE € 1 750 000,00 Adres EDMOND J SAFRA CAMPUS GIVAT RAM 91904 Jerusalem Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Irit Harat (Ms.) Kierownik naukowy Adi Mizrahi (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych