Cel Understanding the mechanisms underlying the initiation and regulation of transcription remains one of the most fundamental questions in biology. Much of what we know about the transcription process was inferred from experiments on a handful of genes. As these experiments are not realistically scalable, corresponding computational methods building on these findings have emerged; however, these are not accurate enough for annotation of genomes. The limitations reflect that we have no accurate universal model describing transcription initiation; to a large extent, our understanding is based on case stories. Recently, high-throughput methods have been developed to chart the TSS landscape with nucleotide resolution. Using these data, I have dissected promoters at nucleotide level and found patterns that explain the transcription initiation rate for individual nucleotides. The objective for this work is to extend this to the first universal model for how cells select core promoters and associated TSSs. This will have two counterparts: i)prediction of TSSs from DNA sequence given a region of accessible DNA, and ii)prediction of DNA accessibility based on DNA sequences and dynamic epigenetic factors. Such a model will be a corner stone of future experimental and computational transcriptome and gene regulation studies. Dziedzina nauki natural sciencesbiological sciencesgeneticsDNAnatural sciencescomputer and information sciencescomputational sciencenatural sciencesbiological sciencesgeneticsnucleotidesnatural sciencesbiological sciencesgeneticsgenomes Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-SG-LS2 - ERC Starting Grant - Genetics,Genomics,Bioinformatics and Systems Biology Zaproszenie do składania wniosków ERC-2007-StG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-SG - ERC Starting Grant Instytucja przyjmująca KOBENHAVNS UNIVERSITET Wkład UE € 812 399,05 Adres NORREGADE 10 1165 Kobenhavn Dania Zobacz na mapie Region Danmark Hovedstaden Byen København Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Katja Pedersen (Ms.) Kierownik naukowy Albin Sandelin (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko KOBENHAVNS UNIVERSITET Dania Wkład UE € 812 399,05 Adres NORREGADE 10 1165 Kobenhavn Zobacz na mapie Region Danmark Hovedstaden Byen København Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Katja Pedersen (Ms.) Kierownik naukowy Albin Sandelin (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych