Strategy of piliated meningococci to cross multicellular defense barriers

Projektinformationen

T4P_CROSSING_BARRIER

ID Finanzhilfevereinbarung: 220784

Abgeschlossenes Projekt

Startdatum 1 September 2008

Enddatum 31 August 2010

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 232 597,61

EU-Beitrag € 232 597,61

Koordiniert durch

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Ziel

The main goal of this proposal is to determine how the deadly bacterial pathogen, Neisseria meningitidis (NM), crosses the blood-tissue barriers and invades the brain and other vital organs. The main hypothesis behind this project is that NM, by interacting with the vascular endothelial cells with its pili, induces a signal that opens cell-to-cell junctions and allows the bacteria to penetrate the natural barriers using the paracellular route rather than the transcellular one as currently accepted. The methodology to be applied involves multidisciplinary approach with advanced imaging techniques, mass spectroscopy, basic cell biology and molecular genetics, and is aimed to take advantage of complementary expertise of involved research partners to solve this burning clinical issue. Understanding the mechanism by which a bacterial pathogen invades the brain and other organs will have consequences beyond the field of medical bacteriology, and will allow insights into regulation of cell polarity. Information gained from this study will be aid in the design of vehicles that mimick signals generated by N.meningitidis and thus contribute to the design of new systems for the delivery of drugs beyond the blood brain barrier.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › genetics
• natural sciences › biological sciences › molecular biology › molecular genetics
• natural sciences › biological sciences › microbiology › bacteriology
• natural sciences › biological sciences › cell biology › cell polarity
• natural sciences › physical sciences › optics › spectroscopy

Schlüsselbegriffe

• Actomyosin
• Blood-Tissue Barrier
• Caveolae
• Cell motility and polarity
• Neisseria meningitidis
• Paracellular Route
• Three-Dimensional Meningococcal Clusters
• Tight Junctions
• Trafficking
• Type IV Pili

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2007-2-1-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Kontakt Verwaltung

Laurence Parmantier (Ms.)

• EU-Beitrag: € 232 597,61
• Adresse: RUE DE TOLBIAC 101 ; 75654 Paris ; Frankreich
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten